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Effect of Valsartan on N-Terminal Pro-Brain Natriuretic Peptide in Patient With Stable Chronic Heart Failure: Comparison With Enalapril

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Author(s)
Young Soo LeeKee Sik KimJin Bae LeeJae Kean RyuJi Yong ChoiByong-Kyu KimSung Gug ChangSeung Ho HurBong Ryeol LeeByung Chun JungGeu Ru HongByung Soo KimTae Ho ParkYoung Dae KimTae Ik KimDong Soo Kim
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean Circulation Journal
Issued Date
2011
Volume
41
Issue
2
Keyword
Brain natriuretic peptideAngiotensin-converting enzyme inhibitorsAngiotensin receptor blockerCongestive heart failure
Abstract
Background and Objectives: The plasma concentration of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is a st-rong prognostic indicator for patients with heart failure (HF) across all stages of the condition. Several clinical trials have de-monstrated convincingly that neurohormonal modulation on the renin angiotensin system (RAS) decreases plasma NT-pro-BNP level and results in favorable outcomes. But there are still limited comparative data on the neuro-hormonal modulatory effects of two RAS inhibitors: angiotensin converting enzyme inhibitor and angiotensin receptor blocker. Subjects and Methods: This study was a prospective, multi-center, randomized, open-label, controlled, and non-inferiority study involving 445 patients with left ventricular ejection fraction (LVEF) less than 45%. Patients were assigned to receive either valsartan (target dose of 160 mg bid) or enalapril (target dose of 10 mg bid) for 12 months. We compared plasma NT-pro-BNP, high sensitive C-reactive protein (hs-CRP) level and echocardiographic parameters before and after treatment with valsartan or enalapril. Results: The NT-pro-BNP and hs-CRP levels were significantly decreased after 12 months of treatment with valsartan and enalapril. The percentage change was similar between both groups. LVEF improved and left ventricular internal dimensions were decreased in both groups, and there were no significant differences between two groups. Conclusion: Valsartan is as effective on improving plasma NT-pro-BNP level as enalapril in patients with stable chronic HF.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine
Citation
Young Soo Lee et al. (2011). Effect of Valsartan on N-Terminal Pro-Brain Natriuretic Peptide in Patient With Stable Chronic Heart Failure: Comparison With Enalapril. Korean Circulation Journal, 41(2), 61–67. doi: 10.4070/kcj.2011.41.2.61
Type
Article
ISSN
1738-5520
DOI
10.4070/kcj.2011.41.2.61
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36050
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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