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Impact of Optimal Stent Expansion on Late Outcomes After Sirolimus-Eluting Stent Implantation: An Intravascular Ultrasound Study

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Author(s)
Chang-Wook NamKwon-Bae KimSeung-Ho HurYun-Kyeong ChoHyung Seop KimSeong-Wook HanYoon-Nyun KimIn-Sung ChungYoung-Soo LeeKee-Sik Kim
Keimyung Author(s)
Nam, Chang WookKim, Kwon BaeHur, Seung HoCho, Yun KyeongKim, Hyung SeopHan, Seong WookKim, Yoon NyunChung, In Sung
Department
Dept. of Internal Medicine (내과학)
Dept. of Preventive Medicine (예방의학)
Journal Title
Korean Circulation Journal
Issued Date
2007
Volume
37
Issue
6
Keyword
Intravascular ultrasonographyStentsOutcomes
Abstract
Background and Objectives : Sirolimus-eluting stents (SESs) have a considerably lower optimal minimal stent area (MSA) threshold compared to bare metal stents (BMSs). In the SIRIUS IVUS sub study, the absolute optimal stent expansion (OSE) of SESs was described as ≥5.0 mm2. The purpose of this study was to evaluate the impact of the OSE on long-term outcomes following SES implantation using absolute IVUS criteria.
Subjects and Methods : The study included 157 patients (BMS: 57; SES; 100), who underwent 6-month follow-up angiography and 18-month clinical follow-up after bare metal stent or drug-eluting stent (DES) implantation. According to the absolute measurement IVUS criteria, patients were divided into two groups: OSE and non-OSE. The IVUS criteria for OSE were MSA ≥6.5 mm2 for BMS implantation and MSA ≥5.0 mm2 for SES implantation. Results : Angiographic binary restenosis was higher in the non-OSE than the OSE group with BMS (33.3% vs. 11.4%; p<0.039), but the rates were similar between the two groups with SES (4.5% vs. 3.2%; p=1.00). With the BMS, the MACE rates were 5.7% and 30% in the OSE and non-OSE group, respectively (p=0.017). However, with the SES, the MACE rates were similar between the two groups (OSE group, 3.2% vs. non-OSE group, 4.5%, p=1.00). Conclusion : After SES implantation, there were no significant differences in the late outcomes in relation to the achievement of absolute OSE. A variety of restenosis related factors should be considered for better outcomes after DES implantation. Therefore, the concept of OSE in the era of DESs might need to be revisited.
Keimyung Author(s)(Kor)
남창욱
김권배
허승호
조윤경
김형섭
한성욱
김윤년
정인성
Publisher
School of Medicine
Citation
Chang-Wook Nam et al. (2007). Impact of Optimal Stent Expansion on Late Outcomes After Sirolimus-Eluting Stent Implantation: An Intravascular Ultrasound Study. Korean Circulation Journal, 37(6), 244–250. doi: 10.4070/kcj.2007.37.6.244
Type
Article
ISSN
1738-5520
DOI
10.4070/kcj.2007.37.6.244
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36055
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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