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Relationship Between Obesity and N-Terminal Brain Natriuretic Peptide Level as a Prognostic Value After Acute Myocardial Infarction

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Author(s)
Seon Gyu ChoiMyung Ho JeongYoungkeun AhnJeong Gwan ChoJung Chaee KangShung Chull ChaeSeung Ho HurTaek Jong HongYoung Jo KimIn Whan SeongJei Keon ChaeJay Young RhewIn Ho ChaeMyeong Chan ChoJang Ho BaeSeung Woon RhaChong Jin KimDonghoon ChoiYang Soo JangJunghan YoonWook Sung ChungKi Bae SeungSeung Jung Park
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean Circulation Journal
Issued Date
2010
Volume
40
Issue
11
Keyword
Brain natriuretic peptideObesityMyocardial infarction
Abstract
Background and Objectives: Recently, the prognostic value of N-terminal brain natriuretic peptide (NT-proBNP) in acute coronary syndrome has been demonstrated in many studies. However, NT-proBNP levels are influenced by various factors such as sex, age, renal function, heart failure severity, and obesity. NT-proBNP concentrations tend to decrease with higher body mass index (BMI). The aim of this study was to examine the influence of obesity on NT-proBNP as a predictive prognostic factor in acute myocardial infarction (AMI) patients. Subjects and Methods : Using data from the Korea Acute Myocardial Infarction Registry (January 2005 to September 2008), 2,736 AMI patients were included in this study. These patients were divided into men (n=1,972, 70%) and women (n=764, 30%), and were grouped according to their BMIs. Major adverse cardiac events (MACE) during 1 year clinical follow-up were evaluated. Results: NT-proBNP was significantly higher in lower BMI (p<0.001). Mean NT-proBNP levels of each obesity group were 2,393±4,022 pg/mL in the lean group (n=875), 1,506±3,074 pg/mL in the overweight group (n=724) and 1,100±1,137 pg/mL in the obese group (n=1,137) (p<0.01). NT-proBNP was an independent prognostic factor of AMI in obese patients by multivariative analysis of independent risk factors of MACE (p=0.01). Conclusion: NT-proBNP is lower in obese AMI patients than in non-obese AMI patients, but NT-proBNP is still of independent prognostic value in obese AMI patients.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine
Citation
Seon Gyu Choi et al. (2010). Relationship Between Obesity and N-Terminal Brain Natriuretic Peptide Level as a Prognostic Value After Acute Myocardial Infarction. Korean Circulation Journal, 40(11), 558–564. doi: 10.4070/kcj.2010.40.11.558
Type
Article
ISSN
1738-5520
DOI
10.4070/kcj.2010.40.11.558
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36060
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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