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The Impact of Moderate to Severe Renal Insufficiency on Patients With Acute Myocardial Infarction

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Author(s)
Jihyun SonSeung-Ho HurIn Cheol KimYun-Kyeong ChoHyoung-Seob ParkHyuck-Jun YoonHyungseop KimChang-Wook NamYoon-Nyun KimKwon-Bae Kim
Keimyung Author(s)
Hur, Seung HoKim, In CheolCho, Yun KyeongPark, Hyoung SeobYoon, Hyuck JunKim, Hyung SeopNam, Chang WookKim, Yoon NyunKim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean Circulation Journal
Issued Date
2011
Volume
41
Issue
6
Keyword
Renal insufficiencyMyocardial infarctionPercutaneous transluminal coronary angioplasty
Abstract
Background and Objectives: Renal insufficiency (RI) has been reported to be associated with unfavorable clinical outcomes in patients undergoing percutaneous coronary interventions (PCI). However, little data is available regarding the impact of moderate to severe RI on clinical outcomes in patients with acute myocardial infarction (AMI) undergoing PCI. Subjects and Methods: Between March 2003 and July 2007, 878 patients with AMI who underwent PCI were enrolled. Based on estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease (MDRD) equation, patients were divided into two groups: eGFR <60 mL/min·m2 (moderate to severe RI, group A) and eGFR ≥60 mL/min·m2 (normal to mild RI, group B). The primary endpoint was all-cause mortality at 1-year after successful PCI. The secondary endpoints were non-fatal myocardial infarction (MI), target lesion revascularization (TLR), target vessel revascularization (TVR), stent thrombosis (ST) and major adverse cardiac events (MACE) at 1-year. Results: In group A, patients were more often male and older, with diabetes and hypertension. Compared to patients in group B, group A showed significantly higher incidences of all-cause mortality, cardiac mortality, non-fatal MI and MACE. The needs of TLR and TVR, and the incidence of ST were not significantly different between the two groups. Independent predictors of 1-year mortality were eGFR <60 mL/min·m2, male gender, older age and a lower left ventricular ejection fraction. Conclusion: In patients with AMI, moderate to severe RI was associated with mortality and MACE at 1-year after successful PCI. In addition, eGFR <60 mL/min·m2 was a strong independent predictor of 1-year mortality.
Keimyung Author(s)(Kor)
허승호
김인철
조윤경
박형섭
윤혁준
김형섭
남창욱
김윤년
김권배
Publisher
School of Medicine
Citation
Jihyun Son et al. (2011). The Impact of Moderate to Severe Renal Insufficiency on Patients With Acute Myocardial Infarction. Korean Circulation Journal, 41(6), 308–312. doi: 10.4070/kcj.2011.41.6.308
Type
Article
ISSN
1738-5820
DOI
10.4070/kcj.2011.41.6.308
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36064
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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