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Efficacy and safety of antiplatelet-combination therapy after drug-eluting stent implantation

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Author(s)
Yun-Kyeong ChoChang-Wook NamHyoung-Seob ParkHyuck-Jun YoonHyungseop KimSeung-Ho HurYoon-Nyun KimJang-Hoon LeeDong-Heon YangBong-Ryeol LeeByung-Chun JungWoong KimJong-Seon ParkJin-Bae LeeKee-Sik KimKwon-Bae Kim
Keimyung Author(s)
Cho, Yun KyeongNam, Chang WookPark, Hyoung SeobYoon, Hyuck JunKim, Hyung SeopHur, Seung HoKim, Yoon NyunKim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean Journal of Internal Medicine
Issued Date
2014
Volume
29
Issue
2
Keyword
AspirinClopidogrelDrug combinations
Abstract
Background/Aims: Combination single-pill therapy can improve cost-effectiveness in a typical medical therapy. However, there is a little evidence about the efficacy and tolerability of combination single-pill antiplatelet therapy after percutaneous coronary intervention (PCI) with drug-eluting stents (DES). Methods: From June to November 2012, in total, 142 patients who met the following criteria were enrolled: at least 18 years old; successful PCI with DES at least 3 months earlier; and regular medication of aspirin and clopidogrel with no side effects. After VerifyNow P2Y12 and aspirin assays, the combination single pill of aspirin and clopidogrel was given and laboratory tests were repeated 6 weeks later. Results: At baseline, the incidence of aspirin resistance, defined as aspirin reaction unit (ARU) ≥ 550, was 9.2%, that of clopidogrel resistance, defined as P2Y12 reaction unit (PRU) ≥ 230, was 46.5%, and that of percent inhibition of PRU < 20% was 32.4%. At follow-up, the incidence of resistance by ARU value was 7.0%, 50.0% by PRU value, and 35.9% by percentage inhibition of PRU, respectively. The mean values of ARU (431.5 ± 63.6 vs. 439.8 ± 55.2; p = 0.216) and PRU (227.5 ± 71.4 vs. 223.3 ± 76.0; p = 0.350) were not significantly different before versus after antiplateletcombination single-pill therapy. Five adverse events (3.5%) were observed during the study period. Conclusions: Combination single-pill antiplatelet therapy, which may reduce daily pill burden for patients after PCI with DES, demonstrated similar efficacy to
separate dual-pill antiplatelet therapy.
Keimyung Author(s)(Kor)
조윤경
남창욱
박형섭
윤혁준
김형섭
허승호
김윤년
김권배
Publisher
School of Medicine
Citation
Yun-Kyeong Cho et al. (2014). Efficacy and safety of antiplatelet-combination therapy after drug-eluting stent implantation. Korean Journal of Internal Medicine, 29(2), 210–216. doi: 10.3904/kjim.2014.29.2.210
Type
Article
ISSN
1226-3303
DOI
10.3904/kjim.2014.29.2.210
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36093
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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