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No Detection of Simian Virus 40 in Malignant Mesothelioma in Korea

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Author(s)
Minseob EomJamshid Abdul-GhafarSun-Mi ParkJoung Ho HanSoon Won HongKun Young KwonEun Suk KoLucia KimWan Seop KimSeung Yeon HaKyo Young LeeChang Hun LeeHye Kyoung YoonYoo Duk ChoiMyoung Ja ChungSoon-Hee Jung
Keimyung Author(s)
Kwon, Kun Young
Department
Dept. of Pathology (병리학)
Journal Title
Korean Journal of Pathology
Issued Date
2013
Volume
47
Issue
2
Keyword
ImmunohistochemistryMesotheliomaPolymerase chain reactionSimian virus 40
Abstract
Background: Simian virus 40 (SV40), a polyomavirus, was discovered as a contaminant of a human polio vaccine in the 1960s. It is known that malignant mesothelioma (MM) is associated with SV40, and that the virus works as a cofactor to the carcinogenetic effects of asbestos. However, the reports about the correlation between SV40 and MM have not been consistent. The purpose of this study is to identify SV40 in MM tissue in Korea through detection of SV40 protein and DNA. Methods: We analyzed 62 cases of available paraffin-blocks enrolled through the Korean Malignant Mesothelioma Surveillance System and performed immunohistochemistry for SV40 protein and real-time polymerase chain reaction (PCR) for SV40 DNA. Results: Of 62 total cases, 40 had disease involving the pleura (64.5%), and 29 (46.8%) were found to be of the epithelioid subtype. Immunostaining demonstrated that all examined tissues were negative for SV40 protein. Sufficient DNA was extracted for real-time PCR analysis from 36 cases. Quantitative PCR of these samples showed no increase in SV40 transcript compared to the negative controls. Conclusions: SV40 is not associated with the development of MM in Korea.
Keimyung Author(s)(Kor)
권건영
Publisher
School of Medicine
Citation
Minseob Eom et al. (2013). No Detection of Simian Virus 40 in Malignant Mesothelioma in Korea. Korean Journal of Pathology, 47(2), 124–129. doi: 10.4132/KoreanJPathol.2013.47.2.124
Type
Article
ISSN
1738-1843
DOI
10.4132/KoreanJPathol.2013.47.2.124
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36102
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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