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Factors of Compliance in Patients with Hypercholesterolemia Using Rosuvastatin in Primary Care

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Author(s)
Hye Young KimJung Ah LeeYoung Sik KimSung SunwooHan Jin OhChang Sup KimKeunsang YumChangjin ChoiYoo Seock JeongSang-Wook SongDae Hyun KimYoung Sung Kim
Keimyung Author(s)
Kim, Dae Hyun
Department
Dept. of Family Medicine (가정의학)
Journal Title
Korean Journal of Family Medicine
Issued Date
2012
Volume
33
Issue
5
Keyword
HypercholesterolemiaComplianceRosuvastatinLipid Lowering Therapy
Abstract
Background: In order to evaluate the factors of compliance with a lipid lowering therapy, a prospective observational study of patients with hypercholesterolemia using rosuvastatin was carried out. Methods: A total of 2,607 patients who were newly prescribed rosuvastatin were enrolled from 32 family physicians in Korea from March 2009 to December 2009. Of them, 301 patients were excluded due to incomplete data or follow-up compliance data. The patients were regularly observed to ascertain the compliance associated with rosuvastatin at intervals of 12 and 24 weeks. We collected risk factors for the compliance using a structured questionnaire. The criteria for evaluating compliance are to measure clinic attendance, to assess the continuity of therapy, and to calculate the percentage of doses taken. Results: Among a total of 2,306 patients, the degree of compliance was 54.1%. According to logistic regression analysis, the factors for compliance with the lipid lowering drug included old age (odds ratio [OR], 2.68; 95% confidence interval [CI], 2.09 to 3.45), frequent exercise (OR, 1.76; 95% CI, 1.43 to 2.18), previous statin therapy (OR, 4.02; 95% CI, 3.22 to 5.01), hypertension (OR, 1.80; 95% CI, 1.48 to 2.19), diabetes mellitus (OR, 2.20; 95% CI, 1.69 to 2.87), concomitant medication (OR, 2.28; 95% CI, 1.88 to 2.77), and high coronary heart disease (CHD) risk category (OR, 1.82; 95% CI, 1.39 to 2.38). The compliance decreased with high low density lipoprotein cholesterol levels (OR, 0.20; 95% CI, 0.16 to 0.26). Conclusion: The compliance of patients using rosuvastatin was 54.1% in primary care. The factors related to higher compliance were old age, regular exercise, previous statin therapy, concomitant medication, presence of hypertension or diabetes, and higher CHD risk level.
Keimyung Author(s)(Kor)
김대현
Publisher
School of Medicine
Citation
Hye Young Kim et al. (2012). Factors of Compliance in Patients with Hypercholesterolemia Using Rosuvastatin in Primary Care. Korean Journal of Family Medicine, 33(5), 253–261. doi: 10.4082/kjfm.2012.33.5.253
Type
Article
ISSN
2005-6443
DOI
10.4082/kjfm.2012.33.5.253
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36135
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Family Medicine (가정의학)
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