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간세포암종 환자에서 간동맥화학색전술 후 발생한 급성 간부전의 발생률과 위험인자

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Author(s)
전상훈박경식김영환신요식강민경장병국정우진조광범황재석
Keimyung Author(s)
Park, Kyung SikJang, Byoung KukChung, Woo JinCho, Kwang BumHwang, Jae SeokKim, Young Hwan
Department
Dept. of Internal Medicine (내과학)
Dept. of Radiology (영상의학)
Journal Title
Korean Journal of Gastroenterology
Issued Date
2007
Volume
50
Issue
3
Keyword
Transcatheter arterial chemoembolization(간동맥화학색전술)Carcinoma(암종)hepatocellular(간세포)Hepatic failure(간부전)acute(급성)
Abstract
Background/Aims: Although transcatheter arterial chemoembolization (TACE) is a major treatment modality for unresectable hepatocellular carcinoma (HCC), acute hepatic failure after TACE is not rare. However, reports dealing with this important complication are not good enough and results are often variable. The purpose of this study was to evaluate the incidence and associated risk factors of acute hepatic failure after TACE. Methods: From January 2001 to November 2004, six hundred and thirtytwo TACE sessions were performed in 377 patients (294 men and 83 women). Adriamycin mixed lipiodol solution and gelfoam were used for TACE. Various clinical and radiological factors before and after the procedure were reviewed retrospectively. Univariate and multivariate analyses were performed to evaluate the risk factors associated with the development of acute hepatic failure after TACE. Results: Acute hepatic failure occurred in 76 (12.0%) of the 632 TACE sessions within 14
days. Univariate analysis revealed that Child-Pugh class, 1st TACE, total bilirubin level, number of involved segments, total size of tumor, presence of right portal vein thrombosis (PVT) or main PVT, involvement of segment 1, 5, 6, 7, modified UICC stage, and doses of chemotherapeutic agent were significantly different between the patients with or without hepatic failure after TACE. Among them, elevated total bilirubin (p=0.001, E (β)=1.449), presence of right (p=0.035, E (β)=2.109) or main (p=0.011, E (β)=4.067) PVT were independently
associated factors in multivariate analysis. Conclusions: The incidence of acute hepatic failure after TACE was 12.0%. Elevated bilirubin level and portal vein thrombosis could be considered as the predictive factors for acute hepatic failure after TACE in HCC patients.
Alternative Title
Incidence and Risk Factors of Acute Hepatic Failure after Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma
Keimyung Author(s)(Kor)
박경식
장병국
정우진
조광범
황재석
김영환
Publisher
School of Medicine
Citation
전상훈 et al. (2007). 간세포암종 환자에서 간동맥화학색전술 후 발생한 급성 간부전의 발생률과 위험인자. Korean Journal of Gastroenterology, 50(3), 176–182.
Type
Article
ISSN
1598-9992
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36143
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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