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Surgical impact on serum anti-Müllerian hormone in women with benign ovarian cyst: A prospective study

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Author(s)
Won Kyu JangSu Yeon LimJoon Cheol ParkKyung Ryul LeeAnna LeeJeong Ho Rhee
Keimyung Author(s)
Park, Joon CheolRhee, Jeong Ho
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
Obstetrics & Gynecology Science
Issued Date
2014
Volume
57
Issue
2
Keyword
Anti-Müllerian hormoneBenign ovarian massEndometriomaLaparoscopic cystectomy
Abstract
Objective : The aim of this study was to evaluate the surgical impact of benign ovarian mass on ovarian reserve as measured by serum follicle stimulating hormone (FSH), estradiol (E2) and anti-Müllerian hormone (AMH) levels, antral follicle count (AFC) and ovarian volumes. In addition, the differences in ovarian reserve impairment between endometrioma cystectomy and non-endometrioma cystectomy were investigated. Methods : In this prospective study, 22 patients of reproductive age (range, 18–35 years) with benign ovarian masses were enrolled to undergo laparoscopic cystectomy. Of whom 12 had endometriomas and 10 had non-endometriomas. On early follicular phase (day 3) of the cycle preceding the operation and three months after the laparoscopic cystectomy, serum levels of FSH, E2 and AMH, AFC and ovarian volumes were measured in all patients. Data were analyzed with Mann-Whitney U-test and Wilcoxon rank test using SPSS ver. 12.0 for statistic analysis. Results : Median level of serum AMH was significantly decreased from 5.48 ng/mL (interquartile range [IQR], 2.80–7.47) before cystectomy to 2.56 ng/mL (IQR, 1.74–4.32) 3 months postoperation (P<0.05). On the other hand, no significant differences in FSH, E2, AFC and ovarian volumes were found between the preoperative and three months postoperative levels. In a subgroup analysis of the pathologic type of the ovarian cyst, postoperative serum AMH levels were significantly decreased in the endometrioma group, but not in the non-endometrioma group. Conclusion : Serum AMH levels were significantly decreased after laparoscopic cystectomy without any changes of other ovarian reserve tests.
Keimyung Author(s)(Kor)
박준철
이정호
Publisher
School of Medicine
Citation
Won Kyu Jang et al. (2014). Surgical impact on serum anti-Müllerian hormone in women with benign ovarian cyst: A prospective study. Obstetrics & Gynecology Science, 57(2), 121–127. doi: 10.5468/ogs.2014.57.2.121
Type
Article
ISSN
2287-8572
DOI
10.5468/ogs.2014.57.2.121
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36154
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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