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A Case of Paclitaxel-induced Maculopathy Treated with Methazolamide

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Author(s)
Nam Kyun KooYu Cheol Kim
Keimyung Author(s)
Kim, Yu Cheol
Department
Dept. of Ophthalmology (안과학)
Journal Title
Korean Journal of Ophthalmology
Issued Date
2012
Volume
26
Issue
5
Keyword
Macular edemaMethazolamidePaclitaxel
Abstract
A 54-year-old female patient who had been undergoing anti-cancer chemotherapy and radiotherapy for seven years after surgery for left breast cancer visited our clinic for visual disturbance in the right eye at nine months after paclitaxel administration. The best-corrected visual acuity was 0.5 in the right eye and 1.0 in the left eye. The patient was diagnosed with maculopathy due to paclitaxel administration based on the finding of cystoid macular edema in the right eyeon fundus examination and optical coherence tomography; however, no leakage was detected on fluorescein angiography. Thus, drug replacement was planned. On the other hand, no abnormal finding was observed in the left eye. However, as the anti-cancer effect of paclitaxel is significant, replacing paclitaxel with another agent was not warranted; therefore, maintenance therapy with methazolamide was performed before and after administering the anti-cancer agent. Aggravation of cystoid macular edema was prevented, and vision improvement was achieved by oral maintenance therapy with methazolamide. In addition, the same fundus findings as shown in the right eye were detected in the left eye at 16 months after paclitaxel administration. After administering methazolamide, macular thickness was reduced, and vision was improved in the left eye. Paclitaxel administration was discontinued due to cutaneous metastasis from the breast cancer, and another anti-cancer agent was then administered. No subsequent cystoid macular edema has occurred.
Keimyung Author(s)(Kor)
김유철
Publisher
School of Medicine
Citation
Nam Kyun Koo and Yu Cheol Kim. (2012). A Case of Paclitaxel-induced Maculopathy Treated with Methazolamide. Korean Journal of Ophthalmology, 26(5), 394–397. doi: 10.3341/kjo.2012.26.5.394
Type
Article
ISSN
1011-8942
DOI
10.3341/kjo.2012.26.5.394
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36160
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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