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Cytomegalovirus-associated esophageal ulcer in an immunocompetent infant: When should ganciclovir be administered?

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Author(s)
Hyo-Jeong JangAe Suk KimJin-Bok Hwang
Keimyung Author(s)
Hwang, Jin Bok
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Korean Journal of Pediatrics
Issued Date
2012
Volume
55
Issue
12
Keyword
CytomegalovirusEsophageal ulcerGanciclovir
Abstract
Cytomegalovirus (CMV)-associated esophageal ulcer is rare in immunocompetent infants. The presence of inclusion bodies and
immunohistochemical staining for CMV in biopsy specimens obtained during esophagogastroduodenoscopy (EGD) indicate that such ulcers
occur because of CMV infection. A 7-week-old female infant who experienced frequent vomiting and feeding intolerance was diagnosed
with a massive CMV-associated ulcer in the distal esophagus. The ulcer improved after conservative treatment using proton-pump
inhibitors; however, ganciclovir was not administered. In a follow-up EGD biopsy specimen, no CMV inclusion bodies were present, and
immunohistochemical staining results for this virus were negative. The presence of CMV inclusion bodies indicates active viral replication. If
persistent inclusion bodies or positive immunohistochemical staining for CMV is observed in follow-up biopsy specimens, ganciclovir may
be used to treat CMV-associated esophageal ulcers.
Keimyung Author(s)(Kor)
황진복
Publisher
School of Medicine
Citation
Hyo-Jeong Jang et al. (2012). Cytomegalovirus-associated esophageal ulcer in an immunocompetent infant: When should ganciclovir be administered? Korean Journal of Pediatrics, 55(12), 491–493. doi: 10.3345/kjp.2012.55.12.491
Type
Article
ISSN
1738-1061
DOI
10.3345/kjp.2012.55.12.491
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36199
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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