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Cyclooxygenase-2 Overexpression in Chronic Inflammation Associated with Benign Prostatic Hyperplasia: Is It Related to Apoptosis and Angiogenesis of Prostate Cancer?

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Author(s)
Byung Hoon KimChun Il KimHyuk Soo ChangMi Sun ChoeHye Ra JungDuk Yoon KimChoal Hee Park
Keimyung Author(s)
Kim, Byung HoonKim, Chun IlChang, Hyuk SooPark, Choal HeeChoe, Mi SunJung, Hye Ra
Department
Dept. of Urology (비뇨의학)
Dept. of Pathology (병리학)
Journal Title
Korean Journal of Urology
Issued Date
2011
Volume
52
Issue
4
Keyword
Angiogenesis-inducing agentsApoptosisCyclooxygenase 2Prostatic hyperplasiaProstatic neoplasms
Abstract
Purpose: This study was performed to investigate the relationship between cyclooxygenase-2 (COX-2) expression and apoptosis/angiogenesis in inflammatory and noninflammatory benign prostatic hyperplasia (BPH) and prostate cancer (PC). Materials and Methods: This study involved 64 BPH and 57 PC patients. The BPH histopathologies were classified by the presence of chronic inflammation as follows: noninflammatory
BPH (NI-BPH; n=23) and inflammatory BPH (I-BPH; n=41). The association between the expression of COX-2, expression of Bcl-2, the apoptotic index (AI), expression of vascular endothelial growth factor (VEGF), and microvascular density (MVD) in the prostate was investigated.
Results: An overexpression of COX-2, Bcl-2, and VEGF was observed in cases of PC compared with cases of BPH. In PC, the AI was lower and MVD was higher than in BPH. In NI-BPH, I-BPH, and PC, the overexpression of COX-2, Bcl-2, and VEGF gradually increased. The AI was high in I-BPH, but did not differ significantly between the NI-BPH and I-BPH groups or between the NI-BPH and PC groups. MVD was significantly
high in PC, but no significant difference was found between NI-BPH and I-BPH. A significant correlation was shown between the overexpression of COX-2 and Bcl-2, and COX-2 and VEGF. However, the AI was not correlated with the overexpression of COX-2 or Bcl-2. MVD was correlated with the overexpression of COX-2 and VEGF. Conclusions: COX-2 overexpression in PC is correlated with a decrease in apoptosis and an increase in angiogenesis. Chronic inflammation in BPH causes an overexpression of COX-2, which induces the increased expression of Bcl-2 and VEGF. It is likely that chronic inflammation plays a role in the intermediate step of carcinogenesis in the prostate.
Keimyung Author(s)(Kor)
김병훈
김천일
장혁수
박철희
최미선
정혜라
Publisher
School of Medicine
Citation
Byung Hoon Kim et al. (2011). Cyclooxygenase-2 Overexpression in Chronic Inflammation Associated with Benign Prostatic Hyperplasia: Is It Related to Apoptosis and Angiogenesis of Prostate Cancer? Korean Journal of Urology, 52(4), 253–259. doi: 10.4111/kju.2011.52.4.253
Type
Article
ISSN
2005-6737
DOI
10.4111/kju.2011.52.4.253
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36255
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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