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Early Experience With Active Surveillance in Low-Risk Prostate Cancer Treated

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Author(s)
Ji Yong HaByung Hoon KimChoal Hee ParkChun Il Kim
Keimyung Author(s)
Ha, Ji YongKim, Byung HoonPark, Choal HeeKim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
Korean Journal of Urology
Issued Date
2014
Volume
55
Issue
3
Keyword
Needle biopsyProstate-specific antigenProstatic neoplasmsWatchful waiting
Abstract
Purpose: This study was conducted to describe our early experience with active surveillance (AS). Materials and Methods: Between January 2008 and December 2012, 35 patients were treated with AS. Selection criteria included the following: Gleason score ≤6 with single positive core, clinical stage ≤T1c, prostate-specific antigen (PSA) ≤10 ng/mL, and unremarkable imaging results. On patient follow-up, we regularly measured PSA (every 3–6 months) and performed prostate biopsies (after 1 and 3 years). Results: In the first year of follow-up, prostate biopsies were performed in 25 patients (13 patients, negative for cancer; 7 patients, Gleason score of 6 without progression; 5 patients, progression, treated with radical prostatectomy [RP]). In the third year of follow-up, prostate biopsies were performed in five patients (two patients, negative for
cancer; one patient, Gleason score of 6 without progression; two patients, progression, treated with RP). Seven patients discontinued AS because of increased anxiety, and three patients were lost to follow-up. Overall, seven patients (28%) who experienced progression had a mean PSA doubling time (DT) of 7.54 years. Six patients had a PSA DT of more than 3 years, whereas one had a PSA DT of less than 3 years. This study was limited by its small sample size and short follow-up period. Conclusions: PSA kinetics did not correlate with progression, which suggests that regular biopsies should still be performed. AS is an available treatment option for patients with a low risk of prostate cancer but should only be used in carefully selected patients.
Keimyung Author(s)(Kor)
하지용
김병훈
박철희
김천일
Publisher
School of Medicine
Citation
Ji Yong Ha et al. (2014). Early Experience With Active Surveillance in Low-Risk Prostate Cancer Treated. Korean Journal of Urology, 55(3), 167–171. doi: 10.4111/kju.2014.55.3.167
Type
Article
ISSN
2005-6737
DOI
10.4111/kju.2014.55.3.167
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36256
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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