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Expression of Claudin-1 and -7 in Clear Cell Renal Cell Carcinoma and Its Clinical Significance

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Author(s)
Hong Il ShinByung Hoon KimHyuk Soo ChangChun Il KimHye Ra JungChoal Hee Park
Keimyung Author(s)
Kim, Byung HoonChang, Hyuk SooKim, Chun IlPark, Choal HeeJung, Hye Ra
Department
Dept. of Urology (비뇨의학)
Dept. of Pathology (병리학)
Journal Title
Korean Journal of Urology
Issued Date
2011
Volume
52
Issue
5
Keyword
Claudin 1Claudin 7Renal cell carcinoma
Abstract
Purpose: We investigated the correlations between the expression of claudin-1 and claudin-7 in clear cell renal cell carcinoma (clear cell RCC) and clinical parameters. Materials and Methods: The subjects of this study were 119 patients with confirmed clear cell RCC between January 2000 and December 2007. Their RCC tissues were immunohistochemically stained for claudin-1 and claudin-7. The correlations between the expression of claudin and parameters such as sex, age, body mass index (BMI), tumor size, TNM stage, Furhman nuclear grade, postoperative distant metastasis, and cancer-specific survival were analyzed. Results: Among the total 119 subjects, claudin-1 was expressed in 18 (15.1%) and claudin-7 in 31 (26.1%). Claudin-1 was expressed in patients who were older (p=0.007), who had a greater tumor size (p=0.001), who had a higher pathologic T stage (p=0.009), who had preoperative distant metastasis (p=0.035), and who had a higher Furhman nuclear grade (p=0.004). Claudin-7 was expressed only in patients who had a higher Furhman nuclear grade (p=0.031). The risk of postoperative distant metastasis was associated with the expression of claudin-1 (p<0.001) but not with the expression of claudin-7 (p=0.668). The expression of claudin-1 and -7 was not associated with cancer-specific survival (p>0.05). Conclusions: In clear cell RCC, claudin-1 was expressed in patients who were older and who had a greater tumor size, who had higher T or M stages, and who had a higher Furhman nuclear grade. The expression of claudin-1 was associated with a higher risk of postoperative distant metastasis.
Keimyung Author(s)(Kor)
김병훈
장혁수
김천일
박철희
정혜라
Publisher
School of Medicine
Citation
Hong Il Shin et al. (2011). Expression of Claudin-1 and -7 in Clear Cell Renal Cell Carcinoma and Its Clinical Significance. Korean Journal of Urology, 52(5), 317–322. doi: 10.4111/kju.2011.52.5.317
Type
Article
ISSN
2005-6737
DOI
10.4111/kju.2011.52.5.317
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36260
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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