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Long-Term Effect of Loxoprofen Sodium on Nocturia in Patients with Benign Prostatic Hyperplasia

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Author(s)
Hong Il ShinByung Hoon KimHyuk Soo ChangChoal Hee ParkChun Il Kim
Alternative Author(s)
Kim, Byung HoonChang, Hyuk SooPark, Choal HeeKim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
Korean Journal of Urology
Issued Date
2011
Volume
52
Number
4
Keyword
LoxoprofenNocturiaProstatic hyperplasia
Abstract
Purpose: We evaluated the long-term effects of loxoprofen on nocturia in patients with benign prostatic hyperplasia (BPH). Materials and Methods: Between January 2006 and December 2008, 40 BPH patients with 2 or more episodes of nocturia received an alpha-blocker, 5-alpha reductase inhibitor, and a single dose of 60 mg of loxoprofen at night before sleep for 12 months (Group I). During the same period, 38 BPH patients selected as the control group received an alpha-blocker and 5-alpha reductase inhibitor (Group II). Patients were reevaluated after 3, 6, and 12 months of treatment by the number of nocturia episodes and side effects. Results: After 3 months of treatment, the number of nocturia episodes decreased significantly compared with baseline in both group I and group II (1.9±0.7, 2.1±0.7, respectively, p<0.05). The degree of decrease in nocturia was significantly different between the groups (−1.5±0.9, −1.1±0.9, respectively, p=0.034). After 6 and 12 months, the number of nocturia episodes decreased significantly compared with baseline in both group I and group II (p<0.05), but the degree of decrease was not significantly different between the groups (p>0.05). After 6 and 12 months of treatment in group I, treatment- emergent adverse events, including 5 cases of gastric discomfort (12.5%), 3 cases of leg edema (7.5%), and 1 case of decreased urine volume (2.5%), occurred in 9 of the 40 (22.5%) patients. Conclusions: Loxoprofen can be an effective treatment for patients with nocturia secondary to BPH in the short term. Long-term use of loxoprofen is not recommended because of the side effects.
Affiliated Author(s)
김병훈
장혁수
박철희
김천일
Publisher
School of Medicine
Citation
Hong Il Shin et al. (2011). Long-Term Effect of Loxoprofen Sodium on Nocturia in Patients with Benign Prostatic Hyperplasia. Korean Journal of Urology, 52(4), 265–268. doi: 10.4111/kju.2011.52.4.265
Type
Article
ISSN
2005-6737
DOI
10.4111/kju.2011.52.4.265
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36261
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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