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Usefulness of Preoperative Serum Testosterone as a Predictor of Extraprostatic Extension and Biochemical Recurrence

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Author(s)
Hyoung Jong KimByung Hoon KimChol Hee ParkChun Il Kim
Keimyung Author(s)
Kim, Byung HoonPark, Choal HeeKim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
Korean Journal of Urology
Issued Date
2012
Volume
53
Issue
1
Keyword
Disease progressionProstatic neoplasmsTestosterone
Abstract
Purpose: A great variety of studies on preoperative serum testosterone as a predictor of progression of prostate cancer have been reported recently. The purpose of this study was to investigate the relationship of preoperative serum testosterone levels in patients who underwent radical prostatectomy with prognostic factors. Materials and Methods: Clinical data were collected from 60 patients who underwent radical prostatectomy. The 60 cases were divided into 2 groups according to their preoperative serum testosterone levels: group 1 (n=21), <3 ng/ml; group 2 (n=39), ≥3 ng/ml. The groups were compared according to prog-ression factors. Multivariate logistic regression analysis was performed to determine the correlation between biochemical recurrence and each variable. Results: The incidence of extraprostatic invasions was significantly higher in group 1 with 13 cases in group 1 (61.9%) and 11 cases in group 2 (28.2%) (p=0.011). The incidence of biochemical recurrence was also significantly higher in group 1 with 5 cases in group 1 (23.8%) and 2 cases in group 2 (5.1%) (p=0.032). A low serum testosterone level (≤3 ng/ml) was associated with an increased risk of biochemical recurrence (odds ratio [OR], 13.64; 95% confidence interval [CI], 1.66 to 2.43; p=0.015) and an increased risk of extraprostatic invasions (OR, 4.96; 95% CI, 1.41 to 17.38; p=0.012). Conclusions: The incidence rates of extraprostatic invasions and biochemical recurrence were significantly higher in the group with preoperative average serum testosterone of less than 3 ng/ml. Therefore, these results suggest that preoperative average serum testosterone will be useful in predicting postoperative prostate cancer progression.
Keimyung Author(s)(Kor)
김병훈
박철희
김천일
Publisher
School of Medicine
Citation
Hyoung Jong Kim et al. (2012). Usefulness of Preoperative Serum Testosterone as a Predictor of Extraprostatic Extension and Biochemical Recurrence. Korean Journal of Urology, 53(1), 9–13. doi: 10.4111/kju.2012.53.1.9
Type
Article
ISSN
2005-6737
DOI
10.4111/kju.2012.53.1.9
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36266
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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