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표재성방광암에서 Survivin과 p53 발현의 임상적 의의

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Author(s)
곽동윤하지용장혁수최미선박철희김천일
Keimyung Author(s)
Ha, Ji YongChang, Hyuk SooPark, Choal HeeKim, Chun IlChoe, Mi Sun
Department
Dept. of Urology (비뇨의학)
Dept. of Pathology (병리학)
Journal Title
Korean Journal of Urology
Issued Date
2009
Volume
50
Issue
1
Keyword
Urinary bladder neoplasmsHuman BIRC5 proteinp53 genes
Abstract
Purpose: The prognostic value of p53 remains controversial in transitional cell carcinomas of the bladder. Survivin, an inhibitor of apoptosis, is expressed in many human cancers. Recent studies have reported increased expression of survivin in superficial transitional cell carcinomas of the bladder. We investigated the expression of survivin and p53 and the clinical implications of this expression in superficial transitional cell carcinomas of the bladder. Materials and Methods: Immunohistochemical staining of paraffin sections using a monoclonal antibody for survivin and p53 was performed in 82 cases of superficial transitional cell carcinomas of the bladder. Correlations between the expression of survivin and p53 and clinicopathological features, such as age, multiplicity of tumor, size, recurrence, and progression, were examined. Results: Among 82 cases, positive survivin expression (greater than 20%) was observed in 59 cases. Positive p53 expression (greater than 20%) was
observed in 46 cases. There were no significant differences in age, gender, multiplicity, tumor size, tumor grade, pT stage, recurrence, or progression-free survival between p53-positive and p53-negative groups (p>0.05). Also, there were no significant differences in age, gender, multiplicity, tumor size, tumor grade, or pT stage between survivin-positive and survivinnegative groups (p>0.05). However, recurrent-free and progression-free survivals were significantly lower in the survivin-positive group than in the survivin-negative group (p<0.05). Conclusions: The expression of survivin can be recommended as a useful marker for predicting disease recurrence and progression. Survivin may be superior to p53 as a prognostic factor in superficial transitional cell carcinoma of bladder.
Alternative Title
Clinical Implications of the Expression of Survivin and p53 in Superficial Transitional Cell Carcinoma of the Bladder
Keimyung Author(s)(Kor)
하지용
장혁수
박철희
김천일
최미선
Publisher
School of Medicine
Citation
곽동윤 et al. (2009). 표재성방광암에서 Survivin과 p53 발현의 임상적 의의. Korean Journal of Urology, 50(1), 12~17-12~17. doi: 10.4111/kju.2009.50.1.12
Type
Article
ISSN
0494-4747
DOI
10.4111/kju.2009.50.1.12
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36278
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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