A Polymorphism at –1607 2G in the Matrix Metalloproteinase-1 (MMP-1) Increased Risk of Sudden Deafness in Korean Population But Not at –519A/G in MMP-1

Abstract

Objectives/Hypothesis: Matrix metalloproteinase-1 (MMP-1) is associated with a risk of inflammatory disease and can-cer invasion. Two common etiologies for sudden deafness (SD) are circulatory disturbance and inflammation. The present study aimed to investigate whether MMP-1 polymorphisms are associated with SD. Study Design: Case-control study. Ninety-nine Korean SD patients and 530 normal patients (controls) were used in this study. Methods: Single nucleotide polymorphism (SNP) of MMP-1 (at –1607G/2G and –519A/G) was analyzed using the pyro-sequencing method. Results: At MMP-1 –1607G/2G, the distributions of 2G/2G, G/2G, and G/G genotypes in controls were 36.8%, 44.3%, and 18.9%, respectively, and in SD patients were 46.5%, 48.5%, and 5.1%, respectively. The 2G/2G genotype was found to increase the risk of SD compared with the G/G genotype (codominant model: P ¼ .0029; recessive model: P ¼ .0003). The 2G allele was found to increase the risk of SD compared with the G allele (P ¼ .002). At MMP1 –519A/G, there was no statisti-cally significant increase in the risk of SD. Among haplotypes of MMP-1 polymorphisms –1607G/2G and –519A/G, 2GA and GA were found to be associated with SD (P < .05). Conclusions: These results suggest that the 2G/2G genotype is associated with an increased risk of SD compared with the G/2G and G/G genotypes. Furthermore, the 2G allele may be a risk factor for SD.