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Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population

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Author(s)
Eun Soo KimSeung Won KimChang Mo MoonJae Jun ParkTae Il KimWon Ho KimJae Hee Cheon
Keimyung Author(s)
Kim, Eun Soo
Department
Dept. of Internal Medicine (내과학)
Journal Title
Life Science
Issued Date
2012
Volume
90
Issue
Issues 19-20
Keyword
Behcet's diseaseIL17AIL23RSTAT4Polymorphism
Abstract
Aims: Although polymorphisms in IL23R have recently been proposed to predispose to Behcet's disease (BD), associations between IL23R polymorphisms and intestinal BD have yet to be elucidated. We therefore performed a study to evaluate whether IL17A, IL23R, and STAT4 polymorphisms are associated with susceptibility to intestinal BD in the Korean population. Main methods:

Single nucleotide polymorphisms (SNP) in the IL17A, IL23R, and STAT4 genes were analyzed using DNA sequencing, denaturing high performance liquid chromatography, and TaqMan genotyping assays.

Key findings

Individual polymorphism analysis revealed that the TT genotype of IL17A rs8193036 (odds ratio (OR) 2.10, 95% confidence interval (CI) (1.12–3.92), p = 0.021), and GG + GT genotype of IL23R rs1884444 (OR 1.92, 95% CI (1.03–3.57), p = 0.034) was associated with the development of intestinal BD. When these two genotypes were combined, the risk of BD increased compared to that of patients with no-risk or one-risk genotype (OR 2.21, 95% CI (1.13–4.34), p = 0.021). Furthermore, statistically significant gene–gene interactions were observed between G149R in IL23R vs. rs11685878 in STAT4, rs2275913 in IL17A vs. rs7574865 in STAT4, and rs11889341 in STAT4 vs. rs2275913 in IL17A. The haplotypes of IL17A had a positive association with intestinal BD risks, whereas those of IL23R were protective for disease development.

Significance

Our results indicate that the interaction of specific IL17A, IL23R, and STAT4 SNPs modulate susceptibility to intestinal BD in the Korean population, suggesting that the IL-17/23 axis plays a significant role in disease pathogenesis.

Keywords
Behcet's disease;
IL17A;
IL23R;
STAT4;
Polymorphism
Keimyung Author(s)(Kor)
김은수
Publisher
School of Medicine
Citation
Eun Soo Kim et al. (2012). Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet’s disease in Korean population. Life Science, 90(Issues 19-20), 740–746. doi: 10.1016/j.lfs.2012.03.017
Type
Article
ISSN
0024-3205
Source
https://www.sciencedirect.com/science/article/pii/S0024320512001403?via%3Dihub
DOI
10.1016/j.lfs.2012.03.017
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36303
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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