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Protective Effect of Arabinoxylan against Scopolamine-Induced Learning and Memory Impairment

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Author(s)
Chang-Yul KimGil-Yong LeeGyu Hwan ParkJongwon LeeJung-Hee Jang
Keimyung Author(s)
Jang, Jung Hee
Department
Dept. of Pharmacology (약리학)
Journal Title
Biomolecules & Therapeutics
Issued Date
2014
Volume
22
Issue
5
Keyword
ArabinoxylanBrain-derived neurotrophic factorcAMP response element binding proteinLearning and memoryScopolamine
Abstract
The purpose of this study is to investigate the memory enhancing effect and underlying molecular mechanism of arabinoxylan (AX), a major component of dietary fiber in wheat against scopolamine (SCO)-induced amnesia in Sprague-Dawley (SD) rats. Diverse behavior tests including Y-maze, Morris water maze, and passive avoidance tests were performed to measure cognitive functions. SCO significantly decreased the spontaneous alterations in Y-maze test and step-through latency in passive avoidance test, whereas increased time spent to find the hidden platform in Morris water maze test compared with the sham control group. In contrast, oral administration of AX (25 mg/kg and 50 mg/kg) effectively reversed the SCO-induced cognitive impairments in SD rats. Furthermore, AX treatment up-regulated the expression of brain-derived neurotrophic factor (BDNF) in the cortex and hippocampus via promoting activation of cAMP response element binding protein (CREB). Therefore, our findings suggest that AX can improve SCO-induced learning and memory impairment possibly through activation of CREB and up-regulation of BDNF levels, thereby exhibiting a cognition-enhancing potential.
Alternative Title
Protective Effect of Arabinoxylan against Scopolamine-Induced Learning and Memory Impairment
Keimyung Author(s)(Kor)
장정희
Publisher
School of Medicine
Citation
Chang-Yul Kim et al. (2014). Protective Effect of Arabinoxylan against Scopolamine-Induced Learning and Memory Impairment. Biomolecules & Therapeutics, 22(5), 467–473. doi: 10.4062/Open Access biomolther.2014.063
Type
Article
ISSN
1976-9148
DOI
10.4062/Open Access biomolther.2014.063
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36321
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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