계명대학교 의학도서관 Repository

만성 카드뮴 중독 쥐의 신장기능 장애에 미치는 녹차 Catechin의 영향

Metadata Downloads
Author(s)
최정화박근용송대규배재훈박원균김용진이순재
Keimyung Author(s)
Song, Dae KyuBae, Jae HoonPark, Won Kyun
Department
Dept. of Physiology (생리학)
Dept. of Medical Education (의학교육학)
Journal Title
한국영양학회지
Issued Date
2000
Volume
33
Issue
7
Keyword
CATECHINchronic cadmium-poisoned ratrenal dysfunctionblood pressurechronic cadmium-poisoned rat renal dysfunction
Abstract
The purpose of this study was to investigate the effects of green tea catechin on renal dysfunction and blood presure change in chronic cadmium poisoned rats. Sprague-Dawley male rats weighing 100±10g were randomly assigned to one normal group and three cadmium poisoned groups. Cadmium groups were classified to catechin free diet(Cd-0C group) 0.25% catechin diet(Cd-0.25C group) and 0.5% catechin diet(Cd-0.5C group) according to the levels of catechin supplement. Animals were raids for 20weeks. Cadmium were supplied as drinking water of 50ppm Cd2+ Morphological changes shown through a light microscope and an electro-microscope revealed the mitochondria and tubule epithelial cell edema in Cd -0C group but they were alleviated in catechin supplementation. The urinary β2-microglobulin that measured to observe the glomerular injury were higher in Cd-poisoned groups than in normal group but they was lowered by catechin supplementation. Glomerular filtration ratios(GFR) in Cd-poisoned groups were significantly lower than in normal group but that of catechin supplementation group was similar to normal group. This suggested that catechin protected the kidney from the functional damage. Angiotensin converting enzyme(ACE) activity and blood pressure(BP) in Cd-poisoned groups were significantly higher than in normal group. Heart rate was tended to increase in Cd-poisoned groups. The results indicate that green tea catechin supplementation on chronic cadmium-poisoned rats normalized the renal dysfunction and blood pressure system.
Alternative Title
Effects of Green Tea Catechin on Renal Dysfunction in Chronic Cadmium Poisoned Rats
Keimyung Author(s)(Kor)
송대규
배재훈
박원균
Publisher
School of Medicine
Citation
최정화 et al. (2000). 만성 카드뮴 중독 쥐의 신장기능 장애에 미치는 녹차 Catechin의 영향. 한국영양학회지, 33(7), 725–732.
Type
Article
ISSN
0367-6463
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36352
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Medical Education (의학교육학)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.