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신생아 집중치료실에서 침습 칸디다 감염의 예방

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Author(s)
김천수
Keimyung Author(s)
Kim, Chun Soo
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
소아감염
Issued Date
2011
Volume
18
Issue
1
Keyword
CandidaNeonatal intensive care unitInfection controlFluconazole prophylaxis
Abstract
Invasive Candida infections (ICI) have become the third most common cause of late-onset infection among premature infants in the neonatal intensive care unit (NICU). Risk factors include birth weight less than 1,000 g, exposure to more than two antimicrobials, third generation cephalosporin exposure, parenteral nutrition including lipid emulsion, central venous catheter, and abdominal surgery. Candida colonization of the skin and gastrointestinal tract is an important first step in the pathogenesis of invasive disease. Strict infection control measures against the infection should be done in the NICU. The following practices are likely to contribute to reducing the rate of ICI: (1) restriction of broad-spectrum antibiotics, antacids and steroid; (2) introduction of early feeding and promoting breast milk. Fluconazole prophylaxis may be an effective control measure to prevent Candida colonization and infections in individual units with high incidence of fungal infection. In addition, there is a need of further data including the development of resistant strains and the effect on long-term neurodevelopmental outcomes of infants exposed to drugs before the initiation of routine application of antifungal prophylaxis in the NICU.
Alternative Title
Prevention of Invasive Candida Infections in the Neonatal Intensive Care Unit
Keimyung Author(s)(Kor)
김천수
Publisher
School of Medicine
Citation
김천수. (2011). 신생아 집중치료실에서 침습 칸디다 감염의 예방. 소아감염, 18(1), 15–22.
Type
Article
ISSN
1226-3923
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36356
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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