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Sensory and associated reactions to mineral dusts: Sodium Borate, Calcium Oxide, and Calcium Sulfate

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Author(s)
William S. CainAlfredo A. JalowayskiMichael KleinmanNam-Soo LeeBo-Ryung LeeByung-Hoon AhnKevin MagruderRoland SchmidtBrian K. HillenCraig B. WarrenB. Dwight Culver
Keimyung Author(s)
Ahn, Byung Hoon
Department
Dept. of Otorhinolaryngology (이비인후과학)
Journal Title
Journal of Occupational and Environmental Hygiene
Issued Date
2004
Volume
1
Issue
4
Keyword
chemesthesisdosimetric modelirritationmineral dustnasal secretionoccupational exposure limits
Abstract
Occupational exposure limits (OELs) for irritant dusts have had no quantifiable bases. This study (1) charted chemosensory feel, denoted chemesthesis here, to dusts of calcium oxide (1 to 5 mg/m3), sodium tetraborate pentahydrate [sodium borate] (5 to 40 mg/m3), and calcium sulfate (10 to 40 mg/m3); (2) examined correlates of the chemesthetic sensations; and (3) sought to illuminate the basis for potency. Twelve screened men exercised against a light load while they breathed air in a dome fed with controlled levels of dust for 20 min. Measured parameters included nasal resistance, nasal secretion, minute ventilation, heart rate, blood oxygenation, mucociliary transport time, and chemesthetic magnitude, calibrated to pungency of carbon dioxide. Subjects registered time-dependent feel from exposures principally in the nose, secondarily in the throat, and hardly in the eyes. Calcium oxide had the greatest potency, followed by sodium borate, with calcium sulfate a distant third. Of the physiological parameters, amount of secretion showed the best association with chemesthetic potency. That measure, as well as mucociliary transport time and minute ventilation, went into calculation of mass of dust dissolved into mucus. The calculations indicated that the two alkaline dusts increased in equal molar amounts with time. At equal molar concentrations, they had, to a first approximation, equal chemesthetic magnitude. On the basis of mass concentration in air or dissolved into mucus, calcium oxide and sodium borate differed in potency by a factor just above five, equal to the difference in their molecular weights. This relationship could inform the setting of OELs for a critical effect of irritation.
Keimyung Author(s)(Kor)
안병훈
Publisher
School of Medicine
Citation
William S. Cain et al. (2004). Sensory and associated reactions to mineral dusts: Sodium Borate, Calcium Oxide, and Calcium Sulfate. Journal of Occupational and Environmental Hygiene, 1(4), 222–236. doi: 10.1080/15459620490432150
Type
Article
ISSN
1545-9624
Source
https://www.tandfonline.com/doi/abs/10.1080/15459620490432150
DOI
10.1080/15459620490432150
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36422
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학)
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