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근치적 절제수술로 치료한 간내 담관암의 예후인자

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Author(s)
김영민김용훈임태진강구정
Keimyung Author(s)
Kim, Yong HoonLim, Tae JinKang, Koo Jeong
Department
Dept. of Surgery (외과학)
Journal Title
Korean Journal of Hepato-Biliary-Pancreatic Surgery
Issued Date
2010
Volume
14
Issue
3
Keyword
Intrahepatic cholangiocarcinomaPrognosisSurvivalHepatectomy
Abstract
Purpose: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy, but outcome studies are uncommon. The purpose of this study was to determine outcomes and prognostic factors after surgical resection.
Methods: We reviewed and analyzed retrospectively fifty four patients who were diagnosed as having intrahepatic cholangiocarcinoma and whose tumor was resected surgically between 2001 and 2009. Our analysis focused on survival and on significant prognostic factors affecting survival after surgical resection.
Results: Forty-one subjects (75.9%) were male and twelve (24.1%) were female. The average age was 59.4 years old. For predisposing factors, infestation of clonorchis sinensis plus hepatitis B antigen positivity were 11.1% respectively. Among tumor markers, CA 19-9 was elevated in 50.9% and CEA in 30%. Eighty percent were treated by major hepatectomy. Overall 3 & 5 year-survival rates were 41.8% and 36.2%, and 3 and 5 year disease free survival rates were 37.5% and 28.6%, respectively. By univariate analysis, significant prognostic factors affecting cumulative survival were tumor size, vascular invasion, tumor differentiation, serosal invasion, metastasis to the regional lymph nodes and tumor markers CEA and CA 19-9. By multivariate analysis, only differentiation and metastasis to the lymph nodes were significant.
Conclusion: The prognosis of intrahepatic cholangiocarcinoma is poor but has been improved by curative surgical resection. Tumor factors, tumor differentiation and lymph node metastasis were elucidated as the most significant prognostic factors, and radical surgical resection is the only way to get a better outcome from IHC that has a notoriously poor prognosis.
Alternative Title
Prognostic Factors for Intrahepatic Cholangiocarcinoma Treated with Surgical Resection
Keimyung Author(s)(Kor)
김용훈
임태진
강구정
Publisher
School of Medicine
Citation
김영민 et al. (2010). 근치적 절제수술로 치료한 간내 담관암의 예후인자. Korean Journal of Hepato-Biliary-Pancreatic Surgery, 14(3), 141–148.
Type
Article
ISSN
1738-6349
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36428
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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