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人蔘추출물이 Ovalbumin으로 유도된 喘息의 Cytokine에 미치는 영향

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Author(s)
한상엽변성희권영규신상우서성일권택규김상찬
Keimyung Author(s)
Suh, Seong IlKwon, Taeg Kyu
Department
Dept. of Microbiology (미생물학)
Dept. of Immunology (면역학)
Journal Title
동의생리병리학회지
Issued Date
2005
Volume
19
Issue
2
Keyword
Ginseng RadixAsthmaIL-4IL-5IgGIgE
Abstract
This study was performed to investigate the effect of oral administration of GSRE against the asthma. Asthma
was induced to Balb/c mouse by i.p. injection and aerosol immunization with ovalbumin. It was observed the change
of the eosinophil number in the BALF. Concentrations of IL-4, IL-5 in BALF and splenocyte were assessed by ELISA,
IgG and IgE from serum were calculated by same method. Concentration of IL-4 in splenocyte was significantly
decreased in GSRE group compared with control group. Concentrations of IL-5 from BALF and splenocyte were
significantly decreased in GSRE group compared with control group, respectively. Level of IgE in serum was
significantly decreased in GSRE group compared with control group, but not IgG. We found that the effect of GSRE
extract in asthma was implicated in reductions of IL-4, IL-5 released from Th2 cell, and decreses of IgE, from plasma
cell. These findings suggest that GSRE extract can produce anti-asthmatic effect, which may play a role in
allergen-induced asthma therapy.
Alternative Title
Effects of Ginseng Radix Extract on the Cytokine of Experimental Asthma induced by Ovalbumin
Keimyung Author(s)(Kor)
서성일
권택규
Publisher
School of Medicine
Citation
한상엽 et al. (2005). 人蔘추출물이 Ovalbumin으로 유도된 喘息의 Cytokine에 미치는 영향. 동의생리병리학회지, 19(2), 398–406.
Type
Article
ISSN
1738-7698
Source
http://www.dbpia.co.kr/Journal/ArticleDetail/NODE02385845
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36472
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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