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當歸芍藥散이 마우스 대식세포주의 NO 생성 및 사이토카인 유전자 발현에 미치는 영향

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Author(s)
신상우이영선박종현권택규서성일권영규
Keimyung Author(s)
Kwon, Taeg KyuSuh, Seong Il
Department
Dept. of Immunology (면역학)
Dept. of Microbiology (미생물학)
Journal Title
동의생리병리학회지
Issued Date
2004
Volume
18
Issue
5
Keyword
Dangguijakyak-san(當歸芍藥散)Cell proliferationNOiNOSCytokine
Abstract
The present study was conducted to evaluate the immunomodulatory effects of Dangguijakyak-san(當歸芍藥散). We investigated the effects of cell proliferation in mouse spleen cell and RAW 264.7 macrophages cells. Dangguijakyak-san enhanced mitogenic activity in the dose-response manner in mouse spleen cells and RAW 264.7 macrophages cells. In nitric oxide (NO) synthesis and iNOS mRNA expression by Dangguijakyak-san, Dangguijakyak- san alone had an effect on NO synthesis and iNOS mRNA expression in RAW 264.7 cells. NO production and iNOS mRNA expression which is excessively induced by LPS decreased after treatment of Dangguijakyak-san. The expressions of cytokine gene by Dangguijakyak-san investigated using reverse transcription polymerase chain reaction (RT-PCR). In RT-PCR, IL-1α, IL-1β and IL-6 mRNA expressions induced in Dangguijakyak-san-treated RAW 264.7 cells. These data indicate that 1) Dangguijakyak-san can modulate various immune response and 2) the immunomodulatory effects of Dangguijakyak-san may be, in part, associated with the regulation of NO synthesis, the expressions of these cytokine as well as the mitogenic effect on spleen cells and macrophages cells.
Alternative Title
Effects of Dangguijakyak-san Extract on Nitric Oxide Production and Cytokine Gene Expression in RAW 264.7 Macrophages Cell
Keimyung Author(s)(Kor)
권택규
서성일
Publisher
School of Medicine
Citation
신상우 et al. (2004). 當歸芍藥散이 마우스 대식세포주의 NO 생성 및 사이토카인 유전자 발현에 미치는 영향. 동의생리병리학회지, 18(5), 1443–1448.
Type
Article
ISSN
1738-7698
Source
http://www.dbpia.co.kr/Journal/ArticleDetail/NODE02388344
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36475
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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