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木瓜, 虎杖根 및 乳香 추출물이 Raw 264.7 cell에서 LPS로 유도된 MMP-9 의 활성에 미치는 영향

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Author(s)
이태진김연희서성일신상우김상찬권영규박종욱권택규
Keimyung Author(s)
Suh, Seong IlPark, Jong WookKwon, Taeg Kyu
Department
Dept. of Microbiology (미생물학)
Dept. of Immunology (면역학)
Journal Title
동의생리병리학회지
Issued Date
2006
Volume
20
Issue
1
Keyword
Chaenomeles sinensisPolygonum cuspidatumBoswellia carteriiMMP-9
Abstract
Matrix metalloproteinase-9 (MMP-9) is considered to be an important component in the progression of inflammation. Monocytes/macrophages are prominent at inflammation sites, and activation of these cells by stimulants such as lipopolysaccharide (LPS) leads to the production of significant amounts of MMP-9. Here, we show that LPS-induced MMP-9 production and activation was inhibited by the water extract from the fruit of Chaenomeles sinensis (CS), the root of Polygonum cuspidatum (PC), but increased by the extract from Boswellia carterii (BC). To investigate the mechanism by which those extracts inhibits MMP-9 activation, we examined the level of MMP-9 mRNA expression. We observed a significant change in the MMP-9 expression between LPS alone and LPS plus Chaenomeles sinensis and Polygonum cuspidatum extracts-treated cells. In addition, LPS significantly up-regulated MMP-9 promoter activity in Raw 264.7 cells, which was attenuated by the CS and PS extracts. However, water extracts from Boswellia carterii increased MMP-9 expression and MMP-9 promoter activity which were induced by LPS treatment in Raw 264.7 cells. These data suggest that water extracts from Chaenomeles sinensis and Polygonum cuspidatum can modulate anti-inflammatory immune response, which may be in part associated with the regulation of MMP-9 production and/or activation through the regulation of MMP-9 expression in mouse macrophage cells.
Alternative Title
Effects of Water Extracts from Chaenomeles sinensis, Polygonum cuspidatum and Boswellia carterii on LPS-Induced MMP-9 Activation in Raw 264.7 Cell
Keimyung Author(s)(Kor)
서성일
박종욱
권택규
Publisher
School of Medicine
Citation
이태진 et al. (2006). 木瓜, 虎杖根 및 乳香 추출물이 Raw 264.7 cell에서 LPS로 유도된 MMP-9 의 활성에 미치는 영향. 동의생리병리학회지, 20(1), 37–42.
Type
Article
ISSN
1738-7698
Source
http://www.dbpia.co.kr/Journal/ArticleDetail/NODE02383942
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36476
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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