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소음성 난청에서의 Mitochondrial DNA A3243G, A1555G, A7445G 돌연변이

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Author(s)
홍영습Hisahide이명진곽기영황찬호신동훈곽종영이용환김종민김준연
Keimyung Author(s)
Shin, Dong Hoon
Department
Dept. of Preventive Medicine (예방의학)
Journal Title
생명과학회지
Issued Date
2004
Volume
14
Issue
6
Keyword
Mitochondrial DNA mutationNoise-induced hearing loss
Abstract
Mitochondrial DNA mutations have been reported in recent years in association with sensorineural hering loss. The purpose of this study is to identify the association between the noise-induced sensorineural hearing loss and the A to G mutation at nucleotide 3243, 1555, 7445 of mitochondrial DNA. Study subjects were established by history and chart review, and audiological and clinical data were obtained. Blood was sampled from 214 normal controls, 102 noise-induced hearing loss, and 28 sensorineural hearing loss. The DNA of these individuals were extracted, and mitochondrial DNA fragments were analyzed by polymerase chain reaction. Subsequently, the coding sequence of mitochondrial DNA 3243, 1555, 7445 were sequenced, and compared to the normal sequence, and all sequence variations were analyzed by restriction enzymes. Mitochondrial DNA mutations (3243A→G, 1555A→G, 7445A→G) were not detected by polymerase chain reactions in any patients with noise-induced hearing loss, sensorineural hearing loss, and normal controls. The DNA sequencing of PCR products did not revealed an A to G substitution at nucleotide 3243, 1555, 7445 of mitochondrial DNA. The noise-induced sensorineural hearing loss was not associated with mitochondrial DNA mutation (3243A→G, 1555A→G, 7445A→G).
Alternative Title
Mitochondrial DNA Mutation (3243A→G, 1555A→G, 7445A→G) in Noise-Induced Hearing Loss
Keimyung Author(s)(Kor)
신동훈
Publisher
School of Medicine
Citation
홍영습 et al. (2004). 소음성 난청에서의 Mitochondrial DNA A3243G, A1555G, A7445G 돌연변이. 생명과학회지, 14(6), 913–919.
Type
Article
ISSN
1225-9918
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36518
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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