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치료저항 정신분열증 환자의 Clozapine 효과

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Author(s)
곽경필강병조정철호추동호김주찬김성욱
Keimyung Author(s)
Jung, Chul Ho
Department
Dept. of Psychiatry (정신건강의학)
Institute for Medical Science (의과학연구소)
Journal Title
생물치료정신의학
Issued Date
1998
Volume
4
Issue
1
Keyword
Treatment-resistant schizophreniaClozapineEfficacyPANSSGAFCGI
Abstract
The purpose of this study was to investigate the efficacy of clozapine in the treatment of treatment-resistant schizophrenic patients.
This multicenter open study included 77 patients drawn from 3 hospitals in Taegu. After a wash-out period of 7 days, subjects were treated with clozapine according to a standardized titration and dosage schedule for 12 weeks and evaluated at 4 points ; at baseline, and 4, 8, and 12 weeks of treatment. Patients who tolerated and responded to treatment were maintained on a regimen(100-600㎎/day) of clozapine. The psychiatric severity and functioning status of the patients were assessed by PANSS, CGI, and GAF scale.
The mean dally dosage of clozapine was 333.57±127.0㎎. All rating scores on the end point(N=70) demonstrated a significant improvement compared with baseline. Significant improvements in both PANSS positive and negative subscale scores was as early as week 4 through week 12.
The tolerability of clozapine was generally found to be good. Hypersalivation(90.0%), sedation(66.7%), and constipation(61%) were the most common adverse effects.
Our results suggest that clozapine is an effective antipsychotic drug for the treatment-resistant schizophrenics, who are non-responsive to classical antipsychotic drugs.
Alternative Title
Efficacy of Clozapine in Treatment-Resistant Schizophrenic patients
Keimyung Author(s)(Kor)
정철호
Publisher
School of Medicine
Citation
곽경필 et al. (1998). 치료저항 정신분열증 환자의 Clozapine 효과. 생물치료정신의학, 4(1), 1–11.
Type
Article
ISSN
1225-9454
Source
http://www.dbpia.co.kr/Journal/ArticleDetail/NODE00742599
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36540
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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