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급성 전골수성 백혈병에 대한 Arsenic trioxide(As2O3)의 항암 작용

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Author(s)
송기영박진휘조윤정백원기권기영김흥식강진무
Keimyung Author(s)
Baek, Won KiKwon, Ki YoungKim, Heung SikKang, Chin Moo
Department
Dept. of Microbiology (미생물학)
Dept. of Internal Medicine (내과학)
Dept. of Pediatrics (소아청소년학)
Journal Title
소아과
Issued Date
2000
Volume
43
Issue
3
Keyword
Arsenic trioxideAcute promyelocytic leukemia(APL)Childhood
Abstract
Purpose : Acute promyelocytic leukemia(APL or AML, M3) represents an unique model for cancer research in terms of biological and clinical features. Since 1988, it has been widely confirmed that all-trans retinoic acid(ATRA) can induce complete clinical remission in over 85% of APL patients by a differentiation process, with PML-RARα protein possibly being the direct target of ATRA. However, ATRA treatment has two clinical limitations, namely, retinoic acid syndrome and retinoic resistance. Recently, it has been shown that arsenic trioxide used in some traditional Chinese remedy is very effective in retinoic resistant APL treatment. We tried to observe arsenic effect on cell lines and APL patient cells. Methods : We investigated arsenic trioxide-induced apoptosis on APL, HL60, K562, KPH1 cell lines through MTT assay, DNA fragmentation assay and morphologic features. Results : In MTT assay, cell survival rate decreased as the concentration of arsenic trioxide increased. In DNA fragmentation assay with HL60 cell line, DNA fragmentation was more frequent in high concentrations of arsenic trioxide than in low concentrations. During arsenic trioxide treatment, the morphologic change in bone marrow cells of APL patient, included nuclear differentiation and dark cytoplasmic granule during arsenic trioxide treatment. Serum arsenic reached peak level at 4hr after injection. We experienced a case of a 9-year-old male with APL who had relapsed after cessation of retinoic acid treatment. The patient successfully achieved remission following arsenic trioxide treatment without bone marrow depression and exacerbating bleeding diathesis. Conclusion : Arsenic trioxide can be used effectively to treat APL patients by inducing apoptosis and partial differentiation in tumor cells. The precise cellular and molecular mechanisms of its therapeutic effects remain to be determined.
Alternative Title
Anticancer Effect of Arsenic Triowide in Acute Promyelocytic Leukemia
Keimyung Author(s)(Kor)
백원기
권기영
김흥식
강진무
Publisher
School of Medicine
Citation
송기영 et al. (2000). 급성 전골수성 백혈병에 대한 Arsenic trioxide(As2O3)의 항암 작용. 소아과, 43(3), 327–334.
Type
Article
ISSN
0560-3560
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36676
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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