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자폐 장애 및 기타 전반적 발달장애 : 신경발달학적 병리 소견

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Author(s)
천근아정철호
Keimyung Author(s)
Jung, Chul Ho
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
소아청소년정신의학
Issued Date
2005
Volume
16
Issue
2
Keyword
Autistic disorderNeurodevelopmental pathologyCerebral cortexCerebellumLimbic system
Abstract
Autistic disorder and
other PDD are currently viewed as a largely genetically determined neurodevelopmental disorder, although its underlying biological causes remain to be established. In this review, we examine the available neurodevelopmental literature on autistic disorder and discuss the findings that have emerged. Typical neuropathological observations are rather consistent with respect to the limbic system (increased cell packing density and smaller neuronal size), the cerebellum (decreased number of Purkinje cells) and the cerebral cortex ( >50% >50% of the cases showed features of cortical dysgenesis). However, most of the reported studies had to contend with the problem of small sample sizes, the use of quantification techniques, not free of bias and assumptions, and high percentages of autistic subjects with comorbid mental retardation or epilepsy. Furthermore, data from the limbic system and on age-related changes lack replication by independent groups. It is anticipated that future neuropathological studies held great promise, especially as new techniques such as design-based stereology and gene expression are increasingly implemented and combined, larger samples are analysed, and younger subjects free of comorbidities are investigated.
Alternative Title
AUTISTIC DISORDER AND OTHER PERVASIVE DEVELOPMENTAL DISORDER : NEURODEVELOPMENTAL PATHOLOGY
Keimyung Author(s)(Kor)
정철호
Publisher
School of Medicine
Citation
천근아 and 정철호. (2005). 자폐 장애 및 기타 전반적 발달장애 : 신경발달학적 병리 소견. 소아청소년정신의학, 16(2), 153–159.
Type
Article
ISSN
1225-729X
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36699
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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