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정신분열병에 대한 리스페리돈의 효과 및 안정성(장기투여연구)

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Author(s)
이민수김용구강병조김광수김영훈김희철나철노승호백인호연병길오병훈윤도준윤진상이종범이철전태연정인과정인원지익성채정호한상익서광윤
Keimyung Author(s)
Kim, Hee Cheol
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
신경정신의학
Issued Date
1999
Volume
38
Issue
1
Keyword
schizophreniaRisperidoneEfficacySafety
Abstract
Objectives : The purpose
of this study was to evaluate the long-term efficacy and safety of risperidone in the treatment of Korean schizophrenic patients.
Methods : This multicenter open label study included 116 schizophrenic patients drawn form 19 university hospitals. After a wash-out period of 1 week, the patients were treated with risperidone for 56 weeks and evaluated at 8 points : at baseline, and the 8th, 16th, 24th, 32th, 40th, 48th, 52th weeks of treatment. The dose was started at 2㎎ of risperidone on day 1, and increased to 4㎎ on day 2, and 6㎎ on day 3 - 7 and adjusted to a maximum of 16㎎/day according to the individual's clinical response. The psychiatric and neurological status of the patients was assessed by PANSS. CGI, and ESRS scales.
Results : Eighty-seven(75%) of 116 patients completed the 56-week trial risperidone. Clinical improvement(as defined by a 20% of reduction in total PANSS score at end point) was shown by 92.0% of the patients. The mean dose of risperidone was 5.0㎎/day in the 56 week follow-up. PANSS total scores showed significantly improvements between consecutive two points at baseline, 8th, 16th, 24th, 32th, and 48th week of treatment. CGI scores showed significant reductions between consecutive two points at baseline, 8th, 16th, 24th, and 48th weeks of treatment. There PANSS factors(positive, negative, general) showed a significant improvement from the 8th week of treatment, and, after then, remained improved in the rest of the study period. ESRS showed to no significant change the 56 week trial. Laboratory parameters showed no signifiant changes during the course of treatment.
Conclusion : This multicenter long-term open study suggests that risperidone is a antipsychotic drug with long term efficacy safely in the treatment of schizophrenic patients.
Alternative Title
Efficacy and Safety Profile of Risperidone in Schizophrenia : Long-term Follow-up Study
Keimyung Author(s)(Kor)
김희철
Publisher
School of Medicine
Citation
이민수 et al. (1999). 정신분열병에 대한 리스페리돈의 효과 및 안정성(장기투여연구). 신경정신의학, 38(1), 116–127.
Type
Article
ISSN
1015-4817
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36781
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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