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고혈압 환자에서 혈장 내 Long-Chain Fatty Acids 성분 분석

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Author(s)
김종선권지윤김수경
Keimyung Author(s)
Kim, Soo Kyung
Department
Dept. of Pharmacology (약리학)
Journal Title
임상약리학회지
Issued Date
2011
Volume
19
Issue
2
Keyword
Plasma long-chain fatty acidsHypertensive patients
Abstract
Background: Numerous studies have suggested that polyunsaturated fatty acids(PUFAs)-supplemented diets may decrease cardiovascular morbidity and mortality. Especially, ω-3 PUFAs may exert beneficial effects to the treatment and prevention of dyslipidemias, arrhythmias, atherosclerosis, and hypertension.
Methods: This study investigated plasma lipid profiles including total cholesterol, triglycerides (TG), LDL, HDL, and antioxidant status indicative of vitamin A, vitamin E, malondialdehyde (MDA) and distribution of plasma long-chain fatty acids (C12-C24) in 28 normal subjects and 24 hypertensive patients. Also, the correlation among PUFAs, levels of antioxidant status, and lipid profiles of the subjects were estimated.
Results: The distribution of ω-3 PUFAs, saturated fatty acids, and monounsaturated fatty acids showed significant differences (P<0.05), but that of ω-6 PUFAs did not exhibit significant differences. The ω-6/ω-3 ratio exhibited 36.96 in normal group and 14.29 in the hypertensive patient group. The levels of vitamin A, vitamin E, and MDA were increased significantly in the hypertensive patient group.
Conclusion: PUFA levels were estimated in the hypertensive patients and normal group. The results suggest that dietary intake of proper ω-6/ω-3 ratio is needed for prevention and treatment of hypertension.
Alternative Title
Analysis of Plasma Long-Chain Fatty Acids in Hypertensive Patients
Keimyung Author(s)(Kor)
김수경
Publisher
School of Medicine
Citation
김종선 et al. (2011). 고혈압 환자에서 혈장 내 Long-Chain Fatty Acids 성분 분석. 임상약리학회지, 19(2), 166–179.
Type
Article
ISSN
1225-5467
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/36881
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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