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Puromycin Aminonucleoside 투여로 인한 사구체 족세포의 초미형태학적 변화

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Author(s)
김영호박관규김영만조수열
Keimyung Author(s)
Park, Kwan Kyu
Department
Dept. of Pathology (병리학)
Journal Title
한국전자현미경학회지
Issued Date
1998
Volume
28
Issue
4
Keyword
Rat KidneySEMTEMPuromycin aminonucleosideUrin protein
Abstract
Puromycin aminonucleoside (PAN) nephropathy was induced in a group of Sprague-Dawley rat by a single dose of intraperitoneal Injection to study an ultrastructural change of glomerulus. The experimental rats developed proteinuria three days after PAN injection. Electron microscopic studies of glomeruli showed the loss of epithelial foot processes, formation of cytoplasmic vacuoles, microvillous formation and increased numbers of lysosomes in the cytoplasm of podocytes. It is strongly suggested that proteinuria in PAN nephrosis may be primarily due to a glomerular epithelial lesion, leading to focal disarray of anionic sites or focal defects in the epithelial covering of the basement membrane. The loss of anionic sites in the basement membrane nay be caused by the foot process fusion and the epithelial detachment from the basement membrane.
Alternative Title
Morphological Changes in Glomerular Podocytes in Puromycin Aminonucleoside Induced Nephropathy
Keimyung Author(s)(Kor)
박관규
Publisher
School of Medicine
Citation
김영호 et al. (1998). Puromycin Aminonucleoside 투여로 인한 사구체 족세포의 초미형태학적 변화. 한국전자현미경학회지, 28(4), 577–590.
Type
Article
ISSN
1225-6773
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37159
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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