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미세유동시스템 내에서의 입자의 위치제어 연구

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Author(s)
허윤석
Keimyung Author(s)
Heo, Yun Seok
Department
Dept. of Biomedical Engineering (의용공학과)
Journal Title
한국정밀공학회지
Issued Date
2014
Volume
31
Issue
6
Keyword
MicrofluidicsHerringbone ChipCirculating tumor cellOvarian cancerMotion of Particlemicrofluidicsherringbonechipcirculatingtumorcellovariancancermotionofparticle
Abstract
Circulating tumor cells (CTCs) in the bloodstream of cancer patients provide an accessible source for detection, characterization, and monitoring of nonhematological cancers. The effectiveness of the CTC-Chip for the isolation of ovarian cancer cells was demonstrated by adapting the herringbone-chip (HB-Chip). The motions of the particles on the HB chip were simulated by a unique combination of buoyant, gravitational forces, and helical flows with a computational modeling. The motions of cells are demonstrated by applying polystylene bead and ovarian cancer cells into the microfabricated HB-Chip. The experimental results from beads and cells are well accordance with the simulated ones, as previously reported by Toner group. Thus, I expect that these modeling and experimental skills will play key roles in the clinical applications on CTC isolation as well as the basic research on characterization of CTCs under flow.
Alternative Title
Control of the Motions of Particles in Microfluidic System
Keimyung Author(s)(Kor)
허윤석
Publisher
School of Medicine
Citation
허윤석. (2014). 미세유동시스템 내에서의 입자의 위치제어 연구. 한국정밀공학회지, 31(6), 521–525. doi: 10.7736/KSPE.2014.31.6.521
Type
Article
ISSN
1225-9071
DOI
10.7736/KSPE.2014.31.6.521
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37160
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
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