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저산소성 폐혈관 수축과 토끼 폐동맥 평활근 세포의 외향성 칼륨 전류의 변화

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Author(s)
송대규박명규
Keimyung Author(s)
Song, Dae Kyu
Department
Dept. of Physiology (생리학)
Journal Title
항공우주의학
Issued Date
1999
Volume
9
Issue
2
Keyword
Hypoxic pulmonary vasoconstrictionOutward K currentRedoxPulmonary artery smooth muscle
Abstract
Hypoxic pulmonary vasoconstriction (HPV) is well-known characteristic of pulmonary artery during the exposure of low O2 conditions. It has been demonstrated that hypoxia inhibits an outward K current, thus causing membrane depolarization and calcium influx through the voltage-dependent Ca channels in pulmonary artery smooth muscle cells. Hypoxia induces a reducing condition within the cell. The change of the redox (reduction and oxidation) state in the cells can also modulate the kinetics of ion channels which is influential to membrane potential. Under the assumption that the reducing milieu during hypoxia inhibits the outward K current and vasodilation, we have studied the effects of redox state on the K currents in the pulmonary artery smooth muscle cells of the rabbit using patch-clamp technique. The outward K current was induced by depolarization from holding potential -80 mV. A reducing agent dithiothreitol inhibited the outward K current, whereas an oxidizing agent dithio-bis (5-nitropyridine) potentiated it. The tetraethyl ammonium, a K channel blocker, mainly suppressed the inactivating component of the K current. Another blocker of voltage dependent K channel E4031 had no effect. This results suggest that the reducing state within the cell during hypoxia modulates the outward K current, which leads vasoconstriction through depolarization and Ca influx. This may be one of mechanisms of HPV in contrast to the other arteries of the body to dilate during low O2 tension.
Alternative Title
Hypoxic Pulmonary Vasoconstriction and Change in Outward K Current in Pulmonary Arterial Smooth Muscle Cell of the Rabbit
Keimyung Author(s)(Kor)
송대규
Publisher
School of Medicine
Citation
송대규 and 박명규. (1999). 저산소성 폐혈관 수축과 토끼 폐동맥 평활근 세포의 외향성 칼륨 전류의 변화. 항공우주의학, 9(2), 171–175.
Type
Article
ISSN
1738-2548
Source
http://www.dbpia.co.kr/Journal/ArticleDetail/NODE01373299
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37190
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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