계명대학교 의학도서관 Repository

해마 신경세포에서 흥분성 시냅스 신호전달에 미치는 Brain-derived Neurotrophic Factor의 효과

Metadata Downloads
Author(s)
송대규손은익홍영수배재훈박원균
Keimyung Author(s)
Song, Dae KyuSon, Eun IkBae, Jae HoonPark, Won Kyun
Department
Dept. of Physiology (생리학)
Dept. of Neurosurgery (신경외과학)
Dept. of Medical Education (의학교육학)
Journal Title
항공우주의학
Issued Date
1999
Volume
9
Issue
2
Keyword
BDNFGlutamateSynapic transmissionHippocampla neurons
Abstract
Brain-derived neurotrophic factor (BDNF) rapidly enhances synaptic transmission among the 0ahippocampal neurons in the resting state. This mechanism may be due to the phosphorylation of 0aNMDA receptors through its Trkb receptors on the postsynaptic neuron. In contrast, BDNF also 0ahas a suppressing effect on the synaptic transmission via non-NMDA receptors. The activities of 0anon-NMDA receptors are known to modulate the NMDA receptors activities. This study was to 0ainvestigate, using patch clamp technique, whether the BDNF increases or decreases the 0aglutamate-induced synaptic transmission in which glutamate acts on both NMDA- and non-NMDA 0areceptors. When a postsynaptic neuron was previously excited by a large amount of glutamate, 0aBDNF decreased the synaptic transmission induced by subsequently-applied glutamate. However, 0awhen the signal entered into a postsynaptic neuron was blocked by the application of 0atetrodotoxin, BDNF increased the glutamate-induced responses. These results show that BDNF 0aplays a role in a protection of the neurons against hazardous or uncontrolled activation of 0aglutamate receptors and in an accentuation of the synaptic response when the signal is 0ainevitably diminished.
Alternative Title
Effect of Brain-derived Neurotrophic Factor on Excitatory Synaptic Transmission in Hippocampal Neurons
Keimyung Author(s)(Kor)
송대규
손은익
배재훈
박원균
Publisher
School of Medicine
Citation
송대규 et al. (1999). 해마 신경세포에서 흥분성 시냅스 신호전달에 미치는 Brain-derived Neurotrophic Factor의 효과. 항공우주의학, 9(2), 192–197.
Type
Article
ISSN
1738-2548
Source
http://www.dbpia.co.kr/Journal/ArticleDetail/NODE01373302
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37192
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Medical Education (의학교육학)
1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.