Head-down Suspension 쥐에서 유도된 심장 Natriuretic Peptide mRNA의 발현

Abstract

Background : Head-down suspension (HDS) of rats has evolved as a useful model for the simulation of a microgravity environment. Methods : Unanesthetized, unrestrained, male Sprague-Dawley rats were subjected to either a horizontal position (control rats) of a 45° head-down tilt using the tail-traction rechnique (HDS rats). Result : After 4 week of HDS, the expression of ANP mRNA were decreased in the both right (P<0.05) and left atria. Conclusion : Collectively, these results represent that the cardiac syntheses of natriuretic peptides following 4 weeks fo HDS are attenuated to prevent any decrement of body fluid as a long-term adaptive response to simulated microgravity and ANP and BNP genes have the differential expression in the each chamber of the heart.