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Propofol이 신경간세포의 전압의존성 칼륨통로에 미치는 영향

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Author(s)
김병용배재훈
Keimyung Author(s)
Bae, Jae Hoon
Department
Dept. of Physiology (생리학)
Brain Research Institute (뇌연구소)
Journal Title
항공우주의학
Issued Date
2000
Volume
10
Issue
3
Keyword
PROPOFOLNeural stem cellVoltage-dependent potassium channel
Abstract
Background : Human neural stem cells have at least two types of voltage-dependent potassium channels including inward and outward rectifying potassium channels.
Methods : Voltage-dependent potassium currents were measured in cultured human neural stem cells using the whole cell patch-clamp techniquebefore and after application of 0.1 mM propofol.
Result : Propofol was found to reversibly block the outward rectifying potassium current (p<0.05), while the anesthetics did not alter the characteristics of inward rectifying potassium current.
Conclusion : These results show that propofol may strongly affect the outward potassium channel in human neural stem stells and also suggest a need for investigation into the effect of propofol on the functional regulation of human neural stem cells.
Alternative Title
Effects of Propofol on Voltage-dependent Potassium Channels in Human Neural Stem Cells
Keimyung Author(s)(Kor)
배재훈
Publisher
School of Medicine
Citation
김병용 and 배재훈. (2000). Propofol이 신경간세포의 전압의존성 칼륨통로에 미치는 영향. 항공우주의학, 10(3), 241–246.
Type
Article
ISSN
1738-2548
Source
http://www.dbpia.co.kr/Journal/ArticleDetail/NODE01373316
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37197
Appears in Collections:
3. Research Institutues (연구소) > Brain Research Institute (뇌연구소)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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