Head-down Suspension 쥐에서 유도된 시상하부의 Nariuretic Peptide mRNA 발현 변화

Abstract

Background: Head-down suspension (HDS) of rats has been used as a model for simulation of a microgravity environment. Methods : Unanesthetized, unrestrained, male Sprague-Dawley rats were subjected to either a horizontal position (control rats) or a-45° head down tilt using the tail traction technique (HDS rats). Results: After 4 weeks of HDS, the expression of ANP mRNA expression was significantly (p<0.01) increased in the hypothalamus of HDS rats. Conclusion : These results represent that the hypothalamic syntheses of natriuretic peptides are differently responded and the role of CNP is augumented to compensate for the decrement of ANP action in the central nervous system following 4 weeks of HDS.