13번 삼염색제를 동반한 급성 미분화성 백혈병 1례

Abstract

The diagnosis of acute undifferentiated leukemia is made when the leukemic cells cannot be classified using morphologic and cytochemical analyses, and do not express myeloid or lymphoid antigens. Trisomy 13 is a rare primary chromosomal abnormality in acute leukemia and associated with lineage inconsistency and poor prognosis. We report a rare case of acute undifferentiated leuksmia showing negativity in periodic acid-Schiff(PAS) and myeloperoxidase(MPO) without any lineage-specific cell suface marker expression and having trisomy 13. The patient was a 72-ysar-old male who visited our hospital becauss of anemia and general weakness. On examination, leukocytosis with proliferated blasts(76%) in peripheral blood was noted. Bone marrow aspirate showed blast proliferation(74%) tilth morphologically hand-mirror type. The blast expressed CD34(96%) and HLA-DR(76%) in immunophenotyping. Cytogsnetic study of bone marrow cells showed 46,XY,+13,-21[15]/46,XY[5]. Induction chemotherapy was failed and differentiation to monocytic series was noted.