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Irritable bowel syndrome: Emerging paradigm in pathophysiology

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Author(s)
Yoo Jin LeeKyung Sik Park
Keimyung Author(s)
Lee, Yoo JinPark, Kyung Sik
Department
Dept. of Internal Medicine (내과학)
Journal Title
World journal of Gastroenterology
Issued Date
2014
Volume
20
Issue
10
Abstract
Irritable bowel syndrome (IBS) is one of the most
common gastrointestinal disorders, characterized by
abdominal pain, bloating, and changes in bowel habits.
These symptoms cannot be explained by structural
abnormalities and there is no specific laboratory test
or biomarker for IBS. Therefore, IBS is classified as a
functional disorder with diagnosis dependent on the
history taking about manifested symptoms and careful
physical examination. Although a great deal of research
has been carried out in this area, the pathophysiology
of IBS is complex and not completely understood. Multiple
factors are thought to contribute to the symptoms
in IBS patients; altered gastrointestinal motility, visceral
hypersensitivity, and the brain-gut interaction are
important classical concepts in IBS pathophysiology.
New areas of research in this arena include inflammation,
postinfectious low-grade inflammation, genetic
and immunologic factors, an altered microbiota, dietary
factors, and enteroendocrine cells. These emerging
studies have not shown consistent results, provoking
controversy in the IBS field. However, certain lines of
evidence suggest that these mechanisms are important
at least a subset of IBS patients, confirming that
IBS symptoms cannot be explained by a single etiological
mechanism. Therefore, it is important to keep
in mind that IBS requires a more holistic approach to
determining effective treatment and understanding the
underlying mechanisms.
Keimyung Author(s)(Kor)
이유진
박경식
Publisher
School of Medicine
Citation
Yoo Jin Lee and Kyung Sik Park. (2014). Irritable bowel syndrome: Emerging paradigm in pathophysiology. World journal of Gastroenterology, 20(10), 2456–2469. doi: 10.3748/wjg.v20.i10.2456
Type
Article
ISSN
1007-9327
DOI
10.3748/wjg.v20.i10.2456
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37236
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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