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A Multi-institutional Study on Histopathological Characteristics of Surgically Treated Renal Tumors: the Importance of Tumor Size

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Author(s)
Sun Il KimYeung Deuk ChoiSe Joong KimByung Ha ChungDo Hwan SeongChun Il KimSang Hyeon CheonJin Seon ChoYun Seob SongYoung Sig KimIn Rae ChoDong Hyeon LeeKi Hak Song,11 Hong Sup Kim,12 Joong Shik Lee,13 Won Jae Yang,7 and Sung Joon Hong2
Keimyung Author(s)
Kim, Chun Il
Department
Dept. of Urology (비뇨의학)
Journal Title
Yonsei Medical Journal
Issued Date
2008
Volume
49
Issue
4
Abstract
Purpose: The incidence of accidentally detected small renal
tumors is increasing throughout the world. In this multiinstitutional
study performed in Korea, histopathological
characteristics of contemporarily surgically removed renal
tumors were reviewed with emphasis on tumor size. Materials
and Methods: Between January 1995 and May 2005, 1,702
patients with a mean age of 55 years underwent surgical
treatment at 14 training hospitals in Korea for radiologically
suspected malignant renal tumors. Clinicopathological factors
and patient survival were analyzed. Results: Of the 1,702
tumors, 91.7% were malignant and 8.3% were benign. The
percentage of benign tumors was significantly greater among
those 4 cm (13.2%) than those > 4 cm (4.5%) (p < 0.001).
Among renal cell carcinoma patients, the percentage of tumors
classed as stage T3 was significantly less among tumors
4 cm (5.2%) than those > 4 cm (26.8%) (p < 0.001). The
percentage of tumors classed as Fuhrman's nuclear grades
3 was also significantly less among tumors 4 cm (27.3%)
than tumors > 4 cm (50.9%) (p < 0.001). The 5-year cancerspecific
survival rate was 82.7%, and T stage (p < 0.001), N
stage (p < 0.001), M stage (p = 0.025), and Fuhrman's nuclear
(p < 0.001) grade were the only independent predictors of
cancer-specific survival. Conclusion: In renal tumors, small
tumor size is prognostic for favorable postsurgical histopathologies
such as benign tumors, low T stages, and low Fuhrman's
nuclear grades. Our observations are expected to facilitate
urologists to adopt function-preserving approach in the
planning of surgery for small renal tumors with favorable
predicted outcomes.
Key Words: Kidney neoplasms, renal cell carcinoma, nephrectomy,
surgical pathology
Keimyung Author(s)(Kor)
김천일
Publisher
School of Medicine
Citation
Sun Il Kim et al. (2008). A Multi-institutional Study on Histopathological Characteristics of Surgically Treated Renal Tumors: the Importance of Tumor Size. Yonsei Medical Journal, 49(4), 639–646. doi: 10.3349/ymj.2008.49.4.639
Type
Article
ISSN
0513-5796
DOI
10.3349/ymj.2008.49.4.639
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37246
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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