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Heart Transplantation. A Retrospective Analysis of the Long-Term Results

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Author(s)
Suk Jung ChooJae Joong KimSang Pil KimJun Wan LeeRyu Sang WanNam Hee ParkSang Kwon LeeDong Gon YooJae Won LeeHyun SongCheol Hyun ChungKyung Sun KimMeong Gun Song
Keimyung Author(s)
Park, Nam Hee
Department
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Journal Title
Yonsei Medical Journal
Issued Date
2004
Volume
45
Issue
6
Abstract
Long-term results of orthotopic heart transplantation vary among different institutions. The purpose of the present study was to assess the factors, which might affect long-term survival and complications. Between November 1992 and July 2003, 112 heart transplantations (M/F=89: 23) were performed. The standard technique was used in the first 57 patients and the bicaval technique in the latter 55 patients. Indications for transplantation in decreasing order of frequency were dilated cardiomyopathy (75%), ischemic cardiomyopathy (7%), and others (18%). The mean follow up duration was 51.8 ± 31.3 months with 98 patients remaining alive. Preoperatively, all patients were either in NYHA functional class III or IV. Postoperatively, all patients showed improvement to functional class II or I, except 3 patients that remained in NYHA class III. The mean number of rejection cases within the first year was 0.6 ± 0.8, with humoral rejection noted in 3 cases. The graft vascular disease (GVD) -free survival at 3 and 5 years was 96% and 83%, respectively. The 7-year survival after heart transplantation was 84%. There were 16 deaths, of which infection (n=4) was the most common followed by rejection (n=3), and malignancy (n=2). The present long-term results, were relatively superior to those seen in western countries. The relatively low GVD-free survival rate is thought to have contributed. The complications encountered after transplantation were mostly immunosuppressive drug related, suggesting further potentials for improvement in long-term survival.

Keywords: Standard technique, bicaval technique, heart transplantation, graft vascular disease.
Keimyung Author(s)(Kor)
박남희
Publisher
School of Medicine
Citation
Suk Jung Choo et al. (2004). Heart Transplantation. A Retrospective Analysis of the Long-Term Results. Yonsei Medical Journal, 45(6), 1173–1180. doi: 10.3349/ymj.2004.45.6.1173
Type
Article
ISSN
0513-5796
DOI
10.3349/ymj.2004.45.6.1173
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37248
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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