계명대학교 의학도서관 Repository

The immunogenicity of a single dose of hepatitis A virus vaccines (Havrix® and Epaxal®) in Korean young adults

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Author(s)
Jiseun LimYeong Jun SongWoong Sub ParkHaesook SohnMoo Sik LeeDong Hoon ShinChun Bae KimHwa Sung KimGyung Jae OhMo Ran Ki
Keimyung Author(s)
Shin, Dong Hoon
Department
Dept. of Preventive Medicine (예방의학)
Journal Title
Yonsei Medical Journal
Issued Date
2014
Volume
55
Issue
1
Abstract
Purpose: Assessing the immunogenicity of a single dose of hepatitis A virus (HAV) vaccines is important because some people receive only a single dose. However, previous studies have shown variable results and have not examined the effects of demographic characteristics other than gender. This study was performed to examine the immunogenicity of a single dose of HAV vaccine according to the vaccine type and demographic characteristics in young adults. Materials and Methods: Seronegative medical school students were randomly allocated to receive either Havrix or Epaxal. Results: After approximately 11 months, the seroconversion rate in 451 participants was 80.7%. In men, the Havrix group showed a significantly higher seroconversion rate (81.9%) than the Epaxal group (69.2%), whereas both vaccine groups showed similarly high immunogenicity in women (Havrix: 90.1%, Epaxal: 92.9%; P for interaction=0.062). According to the results of a multivariate analysis, Epaxal showed significantly lower immunogenicity than Havrix only in men. Age, obesity, drinking, smoking, and follow-up time did not significantly affect seroconversion in either gender. Conclusion: The seroconversion rate of single-dose HAV vaccines was low in men, particularly in those who received Epaxal. Our results suggest that gender effects should be considered when comparing the immunogenicity of different HAV vaccines.
Key Words: Hepatitis A virus, hepatitis A vaccine, immune, vaccine, young adults
Keimyung Author(s)(Kor)
신동훈
Publisher
School of Medicine
Citation
Jiseun Lim et al. (2014). The immunogenicity of a single dose of hepatitis A virus vaccines (Havrix® and Epaxal®) in Korean young adults. Yonsei Medical Journal, 55(1), 126–131. doi: 10.3349/ymj.2014.55.1.126
Type
Article
ISSN
0513-5796
DOI
10.3349/ymj.2014.55.1.126
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37259
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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