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인삼 사포닌이 인간면역계 사이토카인 유전자의 발현에 미치는 영향

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Author(s)
박종욱한인숙서성일백원기서민호배지현최병길
Keimyung Author(s)
Park, Jong WookChoe, Byung KilSuh, Seong IlBaek, Won KiSuh, Min Ho
Department
Dept. of Immunology (면역학)
Dept. of Microbiology (미생물학)
Institute for Medical Science (의과학연구소)
Journal Title
고려인삼학회지
Issued Date
1996
Volume
20
Issue
1
Abstract
In order to investigate the Immunomodulatory effects of ginseng, we have studied the effects of ginseng saponin on the proliferation and cytosine gene expression of human pheripheral blood mononuclear cell (PBMC). In the PBMC proliferation assay, total saponin exhibited proliferation inhibition on the PBMC or phytohemagglutinin(PHA)-stimulated PBMC in a dose-dependent fashion. Immunomodulatory effects of ginseng were further investigated using the cytokine gene expression as the indicators. In the reverse transcription-polymerase chain reaction (RT-PCR) test, interleukin (IL)-1, IL-2, IL-3, IL-4, IL-6, IL-13, granulocyte macrophage-colony stimulating factor, tumor necrosis factor (TNF), migration inhibitory factor and transforming growth factor genes were expressed in the PHA-stimulated PBMC 48 hrs after cell culture. Among expressed cytokines, total saponin could increase the expression of IL-1 and TNF of PBMC without stimulation of PHA. All of ginsenosides, $Rb_1$ 수식 이미지, $Rb_2$ 수식 이미지, $Rg_1$ 수식 이미지, Rc, Re, incresed TNF gene expression. Especially, Rb2 (20 g/ml) showed most prominent effect on TNF gene expression and it also slightly increased IL-1 gene expression of PBMC.
Alternative Title
Effects of Ginseng Saponin on the Cytokine Gene Expression in Human Immune System
Keimyung Author(s)(Kor)
박종욱
최병길
서성일
백원기
서민호
Publisher
School of Medicine
Citation
박종욱 et al. (1996). 인삼 사포닌이 인간면역계 사이토카인 유전자의 발현에 미치는 영향. 고려인삼학회지, 20(1), 15–22.
Type
Article
ISSN
1226-8453
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37357
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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