계명대학교 의학도서관 Repository

17α-Hydroxylase 결핍증후군 1예

Metadata Downloads
Author(s)
박근용박기락이정호
Keimyung Author(s)
Park, Keun YongRhee, Jeong Ho
Department
Dept. of Internal Medicine (내과학)
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
대한내분비학회지
Issued Date
1996
Volume
11
Issue
1
Abstract
The single enzyme P-450c17 hydroxylase catalyzes the 17a-hydroxylation of both pregnenolone and progesterone and the side-chain cleavage of 17a-hydroxypregnenolone and 17a-hydroxypro- gesterone to dehydroepiandrosterone and androstenedione. This enzyme is located in the endoplasmic reticulum and consists of a P-450c17 and a specific flavoprotein NADPH-cytochrome P-450 reductase. The clinical picture and hormonal pattern in 17a-hydroxylase deficiency have been consistent in both genotypic sexes with hypergonadotropic hypogonadism in whom the virtual absence of gonadal steroids results in a female phenotype with primary amenorrhea and pseudohermaphro- ditism in the male and underdeveloped secondary sex characteristics and hypermineralocorticoidism with hypertension, hypokalemia, suppressed renin-angiotensin system and extremely reduced aldo-sterone production. A 17-year-old girl visited endocrine clinic because of amenorrhea, absence of pubic and axillary hair, and hypertension. she had elevated levels of serum corticosterone, deoxycorticosterone(DOC), 18-hydroxycorticosterone(18-OHB). Stumulation with ACTH effected minimal increase in the elevated steroids and the ACTH-stimulated 18-OHB to aldosterone ratio was more than 280. These hormonal patterns appear to be homozygote in 17a-hydroxylase deficiency(J Kor Soc Endocrinol 11:102-107, 1996).
Alternative Title
A case of 17α-Hydroxylase Deficiency in 17-Year-Old Girl
Keimyung Author(s)(Kor)
박근용
이정호
Publisher
School of Medicine
Citation
박근용 et al. (1996). 17α-Hydroxylase 결핍증후군 1예. 대한내분비학회지, 11(1), 102–107.
Type
Article
ISSN
2093-596X
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37434
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
Authorize & License
  • Authorize공개
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.