리팜핀 초치료시 발생한 급성 간질성신염 1 예

Abstract

It has been well defined that acute renal failure due to rifampin is more common when drug is given intermittently and resumed later. However acute renal failure due to rifampin has been rarely reported to occur in patients receiving a first course of continuous rifampin therapy in daily dose. Recently the authors experienced a case of interstitial nephritis during the first course of continuous rifampin therapy in a 52-year-old male patient. Fever, elevated BUN and creatinine were identified 10 days after administration of rifampin, 600mg daily with other antituberculosis drugs. Renal biopsy revealed interstitial nephritis. The renal function was normalized in 44 days after cessation of rifampin. The authors report a case of acute interstitial nephritis during the first course of rifampin therapy, with review of literatures.

Key Words: Acute renal failure. Rifampin, Interstitial nephritis

리팜핀에 의한 신부전은 일반적으로 재투여 및 간헐적 투여시에 발생하는 것으로 알려져있으나 초기치료나 매일투여하는 경우에 발생되는 증례는 드문 것으로 되어있다. 저자들은 최근 계명대학 동산의료원 내과에 항결핵제 투여후 호흡곤란으로 입원한 52세 남자에서 리팜핀 초치료 및 매일투여후 급성간질성신염으로 인한 비핍뇨성 신부전이 발생한 1예를 경험하였기에 보고하는 바이다.