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말단 비대증을 동반한 갑상선자극호르몬 분비 뇌하수체 선종 1예

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Author(s)
하유진김미경김혜순김일만임만빈최미선박근규
Keimyung Author(s)
Kim, Mi KyungKim, Hye SoonPark, Keun GyuKim, ElYim, Man BinChoe, Mi Sun
Department
Dept. of Internal Medicine (내과학)
Dept. of Neurosurgery (신경외과학)
Dept. of Pathology (병리학)
Journal Title
대한내과학회지
Issued Date
2009
Volume
77
Issue
1
Abstract
Growth hormone (GH) and thyrotropin (TSH)-secreting pituitary adenomas are very rare and account for only 0.5% of all pituitary
adenomas. We report a case of a GH/TSH-secreting pituitary adenoma in a 53-year-old male patient. He presented with symptoms
of thyrotoxicosis, clinical features of acromegaly, and diabetes mellitus. The laboratory examinations showed high serum levels
of free T4, TSH, and free alpha-subunit. Additionally, serum levels of GH and insulin-like growth factor (IGF-1) were
increased. GH was not suppressed below 1 μg/L by an oral 75 g glucose loading test, and TSH was not stimulated by thyrotropin-
releasing hormone. A sellar MRI showed a large lobulated mass on the pituitary gland, so transcranial surgery was
performed. Immunohistochemical staining showed anti-GH and anti-TSH positive tumor cells in the cytoplasm. Serum GH, IGF-1,
free T4, and TSH levels normalized after surgery. (Korean J Med 77:S97-S102, 2009)
Key Words: Thyrotrophs; Pituitary neoplasm; Acromegaly
갑상선자극호르몬과 성장호르몬을 함께 분비하는 뇌하수
체 선종은 매우 드물다. 말단 비대증을 동반한 갑상선기능항
진증 환자에서 갑상선자극호르몬과 성장호르몬을 함께 분비
하는 뇌하수체 선종을 진단하고 수술 치료 후 갑상선 호르
몬과 성장호르몬이 정상화된 증례를 경험하였기에 보고하고
자 한다.
중심 단어: 갑상샘자극세포; 뇌하수체 종양; 말단비대증
Alternative Title
A case of TSH-secreting pituitary adenoma with acromegaly
Keimyung Author(s)(Kor)
김미경
김혜순
박근규
김엘
임만빈
최미선
Publisher
School of Medicine
Citation
하유진 et al. (2009). 말단 비대증을 동반한 갑상선자극호르몬 분비 뇌하수체 선종 1예. 대한내과학회지, 77(1), 97–102.
Type
Article
ISSN
1738-9364
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/37693
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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