갑상선 기능항진증 환자에서 방사선 옥소 투여후 Interleukin-6 치의 변화에 관한 연구

Abstract

Interleukin-6(IL-6) is a cytokine secreted from lymphocytes or non-lymphoid cell(monocyte, fibroblast, osteoblast, vascular endothelial cell, or synoviocytes). Increased serum IL-6 concentrations have recently been reported in patients with subacute thyroiditis, possibly because of cytokine release damaged thyroid cells. In this study, IL-6 levels serum T_3, T_4, Thyroglobulin(Tg) and TSH were determined by an radioimmunoassay method in 14 patients treated with radioactive iodine(10mci) for Graves' disease. IL-6 levels were as follows: 23.9+-0.8 fmol/ml(at baseline), 25.4+-1.1 fmol/ml(1hour), 24.7+-0.6 fmol/ml(24hours), 76.8+-2.0 fmol/ml(48hours), 22.8+-0.5 fmol/ml(72hours). There was significant increase in IL-6 values at 48hours after RAI treatment(p<0.01). Serum Tg, T_3 and T_4 also increased after RAI treatment, but no significant correlation could be demonstrated with the increase in L-6. The results of this study support the concept that IL-6 can be regarded as a useful marker of thyroid-destructive processes(J Kor Soc Endocrinol 10: 214-219, 1995).